Strategies to address low drug solubility in discovery and development

HD Williams, NL Trevaskis, SA Charman… - Pharmacological …, 2013 - Elsevier
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Current trends and future perspectives of solid dispersions containing poorly water-soluble drugs

CLN Vo, C Park, BJ Lee - European journal of pharmaceutics and …, 2013 - Elsevier
Over 40% of active pharmaceutical ingredients (API) in development pipelines are poorly
water-soluble drugs which limit formulation approaches, clinical application and …

Self-nanoemulsifying drug delivery systems: formulation insights, applications and advances

AA Date, N Desai, R Dixit, M Nagarsenker - Nanomedicine, 2010 - Taylor & Francis
There has been a resurgence of interest in nanoemulsions for various pharmaceutical
applications since low-energy emulsification methods, such as spontaneous or self …

Review of in vitro digestion models for rapid screening of emulsion-based systems

DJ McClements, Y Li - Food & function, 2010 - pubs.rsc.org
There is increasing interest in understanding and controlling the digestion of emulsified
lipids within the food and pharmaceutical industries. Emulsion-based delivery systems are …

Self-emulsifying drug delivery systems: an approach to enhance oral bioavailability

K Kohli, S Chopra, D Dhar, S Arora, RK Khar - Drug discovery today, 2010 - Elsevier
Self-emulsifying drug delivery systems are a vital tool in solving low bioavailability issues of
poorly soluble drugs. Hydrophobic drugs can be dissolved in these systems, enabling them …

Enhancing intestinal drug solubilisation using lipid-based delivery systems

CJH Porter, CW Pouton, JF Cuine… - Advanced drug delivery …, 2008 - Elsevier
Lipid-based delivery systems are finding increasing application in the oral delivery of poorly
water-soluble, lipophilic drugs. Whilst lipidic dose forms may improve oral bioavailability via …

Lipid-based formulations for oral administration of poorly water-soluble drugs

H Mu, R Holm, A Müllertz - International journal of pharmaceutics, 2013 - Elsevier
Lipid-based drug delivery systems have shown great potentials in oral delivery of poorly
water-soluble drugs, primarily for lipophilic drugs, with several successfully marketed …

Lipid–an emerging platform for oral delivery of drugs with poor bioavailability

S Chakraborty, D Shukla, B Mishra, S Singh - European journal of …, 2009 - Elsevier
The sole objective of pharmaceutical science is to design successful dosage forms which
fulfill the therapeutic needs of the patients effectively. Development of new drug entities is …

[PDF][PDF] Formulation and evaluation of Carica papaya nanoemulsion for treatment of dengue and thrombocytopenia.

S Mandal, V Jaiswal, MK Sagar… - Plant Archives …, 2021 - plantarchives.org
Plant Archives Page 1 e-ISSN:2581-6063 (online), ISSN:0972-5210 Plant Archives Volume 21,
No 1, 2021 pp. 1345-1354 DOI Url: https://doi.org/10.51470/PLANTARCHIVES.2021.v21.no1.179 …

New perspectives on lipid and surfactant based drug delivery systems for oral delivery of poorly soluble drugs

A Müllertz, A Ogbonna, S Ren… - Journal of pharmacy and …, 2010 - academic.oup.com
Objectives The aim of this review is to highlight relevant considerations when implementing
a rational strategy for the development of lipid and surfactant based drug delivery system …