Bone is a dynamic organ maintained by tightly regulated mechanisms. With old age, bone
homeostasis, which is maintained by an intricate balance between bone formation and bone …

A new exciting area in cancer research is the study of cancer stem cells (CSCs) and the
translational implications for putative epigenetic therapies targeted against them …

Osteoporosis is a metabolic disease characterized by decreased bone mineral density and
the destruction of bone microstructure, which can lead to increased bone fragility and risk of …

The transcription factor signal transducer and activator of transcription 3 (STAT3) plays a
central role in cell survival and function. STAT3 has been demonstrated to participate in the …

Mesenchymal stem cells (MSCs) have putative roles in maintaining adult tissue health, and
the functional decline of MSCs has emerged as a crucial pathophysiological driver of …

Objective Hypoxia occurs in tumors, infections, and sites of inflammation, such as in the
affected joints of patients with rheumatoid arthritis (RA). It alleviates inflammatory responses …

Bone metabolism consists of a balance between bone formation and bone resorption, which
is mediated by osteoblast and osteoclast activity, respectively. In order to ensure bone …

Bone-stimulatory therapeutics include bone morphogenetic proteins (eg BMP2), parathyroid
hormone, and antibody-based suppression of WNT antagonists. Inhibition of the epigenetic …

Abstract Purpose of Review Although many signalling pathways have been discovered to be
essential in mesenchymal stem/stromal (MSC) differentiation, it has become increasingly …

Age-associated bone diseases such as osteoporosis (OP) are common in the elderly due to
skeletal ageing. The process of skeletal ageing can be accelerated by reduced proliferation …