Electronic circular dichroism spectroscopy of proteins
Electronic circular dichroism (CD) spectroscopy is an important tool for the elucidation of
biomolecular structure. This review describes the latest progress and developments in …
biomolecular structure. This review describes the latest progress and developments in …
Interaction of polyethylene glycol with cytochrome c investigated via in vitro and in silico approaches
One of the significant proteins that have attracted research groups due to virtue of being a
potent selective anticancer drug target and property of triggering apoptosis upon release in …
potent selective anticancer drug target and property of triggering apoptosis upon release in …
Size-Dependent Interplay of Volume Exclusion Versus Soft Interactions: Cytochrome c in Macromolecular Crowded Environment
Even though there are a great number of possible conformational states, how a protein
generated as a linear unfolded polypeptide efficiently folds into its physiologically active …
generated as a linear unfolded polypeptide efficiently folds into its physiologically active …
Formation of molten globule state in horse heart cytochrome c under physiological conditions: Importance of soft interactions and spectroscopic approach in crowded …
To understand protein folding problem under physiological condition, usually taken as dilute
aqueous buffer at pH 7.0 and 25° C, knowledge of properties of folding intermediates is …
aqueous buffer at pH 7.0 and 25° C, knowledge of properties of folding intermediates is …
Measuring Structural Changes in Cytochrome c under Crowded Conditions Using In Vitro and In Silico Approaches
It is known from in vitro studies that macromolecular crowding in the cell effects protein
structure, stability and function; but predictive studies are relatively unexplored. There are …
structure, stability and function; but predictive studies are relatively unexplored. There are …
Mechanistic insights into the urea-induced denaturation of kinase domain of human integrin linked kinase
Abstract Integrin-linked kinase (ILK), a ubiquitously expressed intracellular Ser/Thr protein
kinase, plays a major role in the oncogenesis and tumour progression. The conformational …
kinase, plays a major role in the oncogenesis and tumour progression. The conformational …
Insights into Fluctuations of Structure of Proteins: Significance of Intermediary States in Regulating Biological Functions
Proteins are indispensable to cellular communication and metabolism. The structure on
which cells and tissues are developed is deciphered from proteins. To perform functions …
which cells and tissues are developed is deciphered from proteins. To perform functions …
Conformational changes in cytochrome c directed by ethylene glycol accompanying complex formation: Protein-solvent preferential interaction or/and kosmotropic …
When proteins interact with solvent or co-solutes with a high specificity and affinity, protein-
ligand complexes may be formed. Such phenomenon may involve the processes like intra …
ligand complexes may be formed. Such phenomenon may involve the processes like intra …
Unravelling the unfolding mechanism of human integrin linked kinase by GdmCl-induced denaturation
Integrin-linked kinase (ILK) is a ubiquitously expressed Ser/Thr kinase which plays
significant role in the cell-matrix interactions and growth factor signalling. In this study …
significant role in the cell-matrix interactions and growth factor signalling. In this study …
Signal Transducer and Activator of Transcription 6 Changes and Protein Frustration by Single Amino Acid Substitutions: Implications for Cancer Progression
SH Alharethi, T Kamal, B Alharbi… - OMICS: A Journal of …, 2023 - liebertpub.com
Signal transducer and activator of transcription 6 (STAT6) is a multifunctional protein that
plays critical functions in cell proliferation, apoptosis, differentiation, and angiogenesis …
plays critical functions in cell proliferation, apoptosis, differentiation, and angiogenesis …