The brain is supplied by an elaborate vascular network that originates extracranially and
reaches deep into the brain. The concept of the neurovascular unit provides a useful …

The concept of the neurovascular unit (NVU), formalized at the 2001 Stroke Progress
Review Group meeting of the National Institute of Neurological Disorders and Stroke …

Glioblastomas are incurable tumors infiltrating the brain. A subpopulation of glioblastoma
cells forms a functional and therapy-resistant tumor cell network interconnected by tumor …

Brain organoids have been used to recapitulate the processes of brain development and
related diseases. However, the lack of vasculatures, which regulate neurogenesis and brain …

Oligodendrocyte precursor cells (OPCs) are a population of tissue-resident glial cells found
throughout the CNS, constituting approximately 5% of all CNS cells and persisting from …

Alzheimer's disease (AD) is conceptualized as a progressive consequence of two hallmark
pathological changes in grey matter: extracellular amyloid plaques and neurofibrillary …

Oligodendrocytes are the myelinating cells of the central nervous system (CNS) that are
generated from oligodendrocyte progenitor cells (OPC). OPC are distributed throughout the …

Fibrosis is a common pathological response to inflammation in many peripheral tissues and
can prevent tissue regeneration and repair. Here, we identified persistent fibrotic scarring in …

Oligodendrocytes have been considered as a functionally homogeneous population in the
central nervous system (CNS). We performed single-cell RNA sequencing on 5072 cells of …

Cerebral small vessel disease (CSVD) is composed of several diseases affecting the small
arteries, arterioles, venules, and capillaries of the brain, and refers to several pathological …