Quantitative measurement of proteins is one of the most fundamental analytical tasks in a
biochemistry laboratory, but widely used immunochemical methods often have limited …

In recent years machine learning has made extensive progress in modeling many aspects of
mass spectrometry data. We brought together proteomics data generators, repository …

Peptide fragmentation spectra are routinely predicted in the interpretation of mass-
spectrometry-based proteomics data. However, the generation of fragment ions has not …

BACKGROUND For many years, basic and clinical researchers have taken advantage of the
analytical sensitivity and specificity afforded by mass spectrometry in the measurement of …

Mass spectrometry-based multiple reaction monitoring (MRM) quantitation of proteins can
dramatically impact the discovery and quantitation of biomarkers via rapid, targeted …

In its early years, mass spectrometry (MS)-based proteomics focused on the cataloging of
proteins found in different species or different tissues. By 2005, proteomics was being used …

Selected reaction monitoring (SRM) performed on triple quadrupole mass spectrometers
has been the reference quantitative technique to analyze small molecules for several …

Protein biomarker discovery produces lengthy lists of candidates that must subsequently be
verified in blood or other accessible biofluids. Use of targeted mass spectrometry (MS) to …

Structural characterization of large multi-subunit protein complexes often requires
integrating various experimental techniques. Cross-linking mass spectrometry (XL-MS) …

Traditional shotgun proteomics used to detect a mixture of hundreds to thousands of
proteins through mass spectrometric analysis, has been the standard approach in research …