Radiotherapy has been used for more than a hundred years to cure or locally control tumors.
Regression of tumors outside of the irradiated field was occasionally observed and is known …

Background Early-stage breast cancer is among the most common cancer diagnoses.
Adjuvant radiotherapy is an essential component of breast-conserving therapy, and several …

Background In the randomised, phase 3 equivalence trial on electron intraoperative
radiotherapy (ELIOT), accelerated partial breast irradiation (APBI) with the use of …

Background Several randomised, phase 3 trials have investigated the value of different
techniques of accelerated partial breast irradiation (APBI) for patients with early breast …

Radiation therapy (RT) is an essential component in the management of breast cancer.
Following breast-conserving surgery (BCS), adjuvant RT is the standard of care for most …

Noninferiority trials are becoming increasing common, but are often poorly reported and
misunderstood. A better understanding of the new components of a noninferiority trial and …

Abstract Background The TARGIT-A trial reported risk-adapted targeted intraoperative
radiotherapy (TARGIT-IORT) during lumpectomy for breast cancer to be as effective as …

Simple Summary Radiation therapy is routinely prescribed for women who undergo breast-
sparing surgery for early breast cancers. Over the years, advancements in diagnosis and …

Background Intraoperative radiation therapy (IORT) has been investigated for patients with
low-risk, early-stage breast cancer. The The North American experience was evaluated by …

Purpose In recent years, results with mature follow-up have been reported for several Phase
III trials randomizing women to receive whole breast irradiation (WBI) versus varying …