Intracellular delivery by membrane disruption: mechanisms, strategies, and concepts

MP Stewart, R Langer, KF Jensen - Chemical reviews, 2018 - ACS Publications
Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

High‐aspect‐ratio nanostructured surfaces as biological metamaterials

SG Higgins, M Becce… - Advanced …, 2020 - Wiley Online Library
Materials patterned with high‐aspect‐ratio nanostructures have features on similar length
scales to cellular components. These surfaces are an extreme topography on the cellular …

Live-seq enables temporal transcriptomic recording of single cells

W Chen, O Guillaume-Gentil, PY Rainer, CG Gäbelein… - Nature, 2022 - nature.com
Single-cell transcriptomics (scRNA-seq) has greatly advanced our ability to characterize
cellular heterogeneity. However, scRNA-seq requires lysing cells, which impedes further …

SpaceM reveals metabolic states of single cells

L Rappez, M Stadler, S Triana, RM Gathungu… - Nature …, 2021 - nature.com
A growing appreciation of the importance of cellular metabolism and revelations concerning
the extent of cell–cell heterogeneity demand metabolic characterization of individual cells …

A Photoelectrochemical Nanoreactor for Single‐Cell Sampling and Near Zero‐Background Faradaic Detection of Intracellular microRNA

HY Wang, YT Xu, B Wang, SY Yu, XM Shi… - Angewandte …, 2022 - Wiley Online Library
Rational utilization of the rich light‐bio‐matter interplay taking place in single‐cell analysis
represents a new technological direction in the field. The light‐fueled operation is expected …

Advances in mass spectrometry based single-cell metabolomics

KD Duncan, J Fyrestam, I Lanekoff - Analyst, 2019 - pubs.rsc.org
Metabolomics has grown into a prominent field contributing to the molecular understanding
of complex biological processes in both health and disease. Furthermore, single-cells are …

An integrated photoelectrochemical nanotool for intracellular drug delivery and evaluation of treatment effect

YF Ruan, FZ Chen, YT Xu, TY Zhang, SY Yu… - Angewandte …, 2021 - Wiley Online Library
With reduced background and high sensitivity, photoelectrochemistry (PEC) may be applied
as an intracellular nanotool and open a new technological direction of single‐cell study …

[HTML][HTML] Driving factors of epiphytic bacterial communities: a review

RO Schlechter, M Miebach… - Journal of advanced …, 2019 - Elsevier
Bacteria establish complex, compositionally consistent communities on healthy leaves.
Ecological processes such as dispersal, diversification, ecological drift, and selection as well …

Electrochemical Single‐Cell Protein Therapeutics Using a Double‐Barrel Nanopipette

XM Shi, YT Xu, BY Zhou, B Wang, SY Yu… - Angewandte …, 2023 - Wiley Online Library
Single‐cell protein therapeutics is expected to promote our in‐depth understanding of how a
specific protein with a therapeutic dosage treats the cell without population averaging …

An integrated electrochemical nanodevice for intracellular RNA collection and detection in single living cell

HY Wang, YF Ruan, LB Zhu, XM Shi… - Angewandte …, 2021 - Wiley Online Library
New tools for single‐cell interrogation enable deeper understanding of cellular
heterogeneity and associated cellular behaviors and functions. Information of RNA …