Multiple sclerosis: immunopathology and treatment update

N Dargahi, M Katsara, T Tselios, ME Androutsou… - Brain sciences, 2017 - mdpi.com
The treatment of multiple sclerosis (MS) has changed over the last 20 years. All
immunotherapeutic drugs target relapsing remitting MS (RRMS) and it still remains a …

[PDF][PDF] An overview of the history, pathophysiology, and pharmacological interventions of multiple sclerosis

IM Dighriri, AA Aldalbahi, F Albeladi, AA Tahiri… - Cureus, 2023 - cureus.com
Multiple sclerosis (MS) is an immune-inflammatory disease that attacks and damages
myelinated axons in the central nervous system (CNS) and causes nontraumatic …

Tanshinone IIA: A phytochemical as a promising drug candidate for neurodegenerative diseases

L Subedi, BP Gaire - Pharmacological research, 2021 - Elsevier
Tanshinones, lipophilic diterpenes isolated from the rhizome of Salvia miltiorrhiza, have
diverse pharmacological activities against human ailments including neurological diseases …

Consensus recommendations for the diagnosis and treatment of multiple sclerosis: 2019 revisions to the MENACTRIMS guidelines

B Yamout, M Sahraian, S Bohlega, M Al-Jumah… - Multiple sclerosis and …, 2020 - Elsevier
With evolving diagnostic criteria and the advent of new oral and parenteral therapies for MS,
most current diagnostic and treatment algorithms need revision and updating. The diagnosis …

Applications and limitations of current markerless motion capture methods for clinical gait biomechanics

L Wade, L Needham, P McGuigan, J Bilzon - PeerJ, 2022 - peerj.com
Background Markerless motion capture has the potential to perform movement analysis with
reduced data collection and processing time compared to marker-based methods. This …

Dietary polyphenols, microbiome, and multiple sclerosis: From molecular anti-inflammatory and neuroprotective mechanisms to clinical evidence

G La Rosa, MS Lonardo, N Cacciapuoti… - International Journal of …, 2023 - mdpi.com
Multiple sclerosis (MS) is a multifactorial, immune-mediated disease caused by complex
gene-environment interactions. Dietary factors modulating the inflammatory status through …

Retinal imaging with optical coherence tomography: a biomarker in multiple sclerosis?

F Costello, JM Burton - Eye and brain, 2018 - Taylor & Francis
Multiple sclerosis (MS) is a progressive neurological disorder characterized by both
inflammatory and degenerative components that affect genetically susceptible individuals …

Interferons and multiple sclerosis: Lessons from 25 years of clinical and real-world experience with intramuscular interferon beta-1a (Avonex)

SL Cohan, BA Hendin, AT Reder, K Smoot, R Avila… - CNS drugs, 2021 - Springer
Abstract Recombinant interferon (IFN) β-1b was approved by the US Food and Drug
Administration as the first disease-modifying therapy (DMT) for multiple sclerosis (MS) in …

Sensitivity of portable low-field magnetic resonance imaging for multiple sclerosis lesions

TC Arnold, D Tu, SV Okar, G Nair, KD Kawatra… - NeuroImage: Clinical, 2022 - Elsevier
Magnetic resonance imaging (MRI) is a fundamental tool in the diagnosis and management
of neurological diseases such as multiple sclerosis (MS). New portable, low-field strength …

Seeking balance: Potentiation and inhibition of multiple sclerosis autoimmune responses by IL-6 and IL-10

SJ Ireland, NL Monson, LS Davis - Cytokine, 2015 - Elsevier
The cytokines IL-6 and IL-10 are produced by cells of the adaptive and innate arms of the
immune system and they appear to play key roles in genetically diverse autoimmune …