Recent evidence supports the notion that mitochondrial metabolism is necessary for the
determination of stem cell fate. Historically, mitochondrial metabolism is linked to the …

Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that
coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes …

Acute kidney injury (AKI) is a prevalent and lethal adverse event that severely affects cancer
patients receiving chemotherapy. It is correlated with the collateral damage to renal cells …

Stomata, the pores formed by a pair of guard cells, are the main gateways for water
transpiration and photosynthetic CO2 exchange, as well as pathogen invasion in land …

Cystic fibrosis (CF) is a lethal autosomal recessive disorder that afflicts more than 70,000
people. People with CF experience multi-organ dysfunction resulting from aberrant …

Reactive oxygen species (ROS) at the right concentration promote cell proliferation in cell
culture, stem cells, and model organisms. However, the mystery of how ROS signaling is …

Lung cancer causes the largest number of cancer-related deaths in the world. Most (85%) of
lung cancers are classified as non-small-cell lung cancer (NSCLC) and small-cell lung …

Abstract Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-
inducible expression of a battery of genes encoding key components of the glutathione …

Respiratory disease is the third leading cause of death in the industrialized world.
Consequently, the trachea, lungs, and cardiopulmonary vasculature have been the focus of …

Viruses hijack host cell metabolism to acquire the building blocks required for replication.
Understanding how SARS-CoV-2 alters host cell metabolism may lead to potential …