Abstract Coagulation factor XII (FXII, Hageman factor, EC= 3.4. 21.38) is the zymogen of the
serine protease, factor XIIa (FXIIa). FXII is converted to FXIIa through autoactivation induced …

Formation of a fibrin clot is mediated by a group of tightly regulated plasma proteases and
cofactors. While this system is essential for minimizing blood loss from an injured blood …

End-stage renal disease (ESRD) patients on chronic hemodialysis have repeated blood
exposure to artificial surfaces that can trigger clot formation within the hemodialysis circuit …

Blood coagulation is thought to be initiated by plasma protease factor VIIa in complex with
the membrane protein tissue factor. In contrast, coagulation factor XII (FXII)–mediated fibrin …

Currently used anticoagulants prevent thrombosis but increase bleeding. We show an
anticoagulation therapy without bleeding risk based on a plasma protease factor XII function …

The plasma zymogens factor XII (fXII) and factor XI (fXI) contribute to thrombosis in a variety
of mouse models. These proteins serve a limited role in hemostasis, suggesting that …

Recent studies indicate that the plasma contact system plays an important role in
thrombosis, despite being dispensable for hemostasis. For example, mice deficient in …

Abstract C1 inhibitor (C1INH) is a multifunctional serine protease inhibitor that functions as a
major negative regulator of several biological pathways, including the contact pathway of …

The classic intrinsic pathway of coagulation is triggered by contact activation of the plasma
protease factor (F) XII, followed by sequential proteolytic activation of FX1 and FIX. While a …

Coagulation factor XII (FXII, Hageman factor) is a plasma protease that in its active form
(FXIIa) initiates the procoagulant and proinflammatory contact system. This name arises from …