Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

Effector, memory and exhaustion are three phenotypes of CD8+ T cell. In tumor
microenvironment (TME), metabolism dysfunction of the three should take the blame for …

Lysosomes coordinate cellular metabolism and growth upon sensing of essential nutrients,
including cholesterol. Through bioinformatic analysis of lysosomal proteomes, we identified …

Tumorigenesis is associated with elevated glucose and glutamine consumption, but how
cancer cells can sense their levels to activate lipid synthesis is unknown. Here, we reveal …

GLUT4 is the primary glucose transporter in adipose and skeletal muscle tissues. Its cellular
trafficking is regulated by insulin signaling. Failed or reduced plasma membrane localization …

Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is the rate-limiting enzyme in
cholesterol synthesis and target of cholesterol-lowering statin drugs. Accumulation of sterols …

The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is
rapidly increasing worldwide at an alarming pace, due to an increase in obesity, sedentary …

Intestinal stem cell (ISC) is a promising therapeutic target for inflammatory bowel disease.
Cholesterol availability is critical for ISC stemness. Low plasma cholesterol is a typical …

Significance: Cholesterol is a type of lipid that plays a crucial role in building and
maintaining cell membranes, producing certain hormones, and aiding in digestion. The two …

Background and Aims NASH is associated with high levels of cholesterol and triglyceride
(TG) in the liver; however, there is still no approved pharmacological therapy. Synthesis of …