Proper execution of cellular function, maintenance of cellular homeostasis and cell survival
depend on functional integration of cellular processes and correct orchestration of cellular …

Mechanistic target of rapamycin (mTOR) is a central signaling hub that integrates networks
of nutrient availability, cellular metabolism, and autophagy in eukaryotic cells. mTOR kinase …

Invadosomes and caveolae are mechanosensitive structures that are implicated in
metastasis. Here, we describe a unique juxtaposition of caveola clusters and matrix …

The mechanistic target of rapamycin complex 1 (mTORC1) is part of the amino acid sensing
machinery that becomes activated on the endolysosomal surface in response to nutrient …

Simple Summary Pancreatic cancer remains one of the most lethal forms of cancer, with
high rates of metastasis. Metastasis is a complex, multi-step process involving many …

Almost all cancer treatments are significantly limited by the strong tumor microenvironment
(TME) fortress formed by abnormal vasculature, dense extracellular matrix (ECM), multidrug …

ABSTRACT SH3PXD2A/TKS5 (SH3 and PX domains 2A) is a scaffold protein that promotes
invadopodia formation and regulates cell migration; therefore, the overexpression of …

Summary The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin
(mTOR) pathway is frequently hyperactivated in triple-negative breast cancers (TNBCs) …

Strategies to develop cancer therapies using inhibitors that target matrix metalloproteinases
(MMPs), particularly membrane type‐1 MMP (MT1‐MMP), have failed. This is predominantly …

Cell migration is oriented by cues from the environment. Such cues are read and interpreted
by the cell and translated into a reorganization of the migration machinery to steer migration …