Potential GSK-3 Binding of Two Novel Pyrazolo [3, 4-g] Isoquinoline Derivatives: Synthesis, Structural Characterization, and Computational Studies
SK Mohamed, S Karthikeyan, EA Bakhite… - Journal of Molecular …, 2025 - Elsevier
Abstract Two novel pyrazolo [3, 4-g] isoquinolines (III and VI) have been synthesized, and
their corresponding structures were confirmed using X-ray crystallography. The short …
their corresponding structures were confirmed using X-ray crystallography. The short …
[PDF][PDF] RhoA/ROCK/GSK3β Signaling: A Keystone in Understanding Alzheimer's
MM Medd, JE Yon, H Dong - 2025 - preprints.org
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
cognitive decline and loss of neuronal integrity. Emerging evidence suggests that RhoA …
cognitive decline and loss of neuronal integrity. Emerging evidence suggests that RhoA …
[PDF][PDF] Glycogen Synthase Kinase 3 (GSK-3) and Suicide: A Systematic Review
JFR RODRIGUES, MFS Rodrigues, LP Rodrigues… - 2024 - preprints.org
Introduction: Glycogen synthase kinase 3 (GSK-3) has been associated with a lot of
diseases, such as Alzheimer's Disease and diabetes. Its role in depression is connected to …
diseases, such as Alzheimer's Disease and diabetes. Its role in depression is connected to …