Cholecystokinin and gastrin receptors (CCK1R and CCK2R) are G protein-coupled
receptors that have been the subject of intensive research in the last 10 years with …

G protein-coupled receptors (GPCRs) can stimulate the mitogen-activated protein kinase
(MAPK) cascade and thereby induce cellular proliferation like receptor tyrosine kinases …

Activation of the transcription factor NF-κB/Rel has been shown to be involved in
inflammatory disease. Here we studied the role of RelA/p65, the main transactivating …

▪ Abstract The intracellular signaling mechanisms by which cholecystokinin (CCK) and other
secretagogues regulate pancreatic acinar function are more complex than originally …

Phospholipase D (PLD) is an enzyme that is widely distributed in bacteria, protozoa, fungi,
plants and animals. Its principal substrate is phosphatidy1-choline (PC) which it hydrolyzes …

We have previously reported that high extracellular Ca2+ stimulates parathyroid hormone-
related protein (PTHrP) release from human prostate and breast cancer cell lines as well as …

The glucagon-like peptide-1 receptor (GLP-1R) is a G-protein-coupled receptor (GPCR) and
an important target in the treatment of type 2 diabetes mellitus (T2DM). Upon stimulation with …

In this paper, the estabished and possible roles of CCK1 and CCK2 receptors in
gastrointestinal (GI) and metabolic diseases are reviewed and available results from human …

▪ Abstract In order to control cell functions, hormones and neurotransmitters generate an
amazing diversity of Ca2+ signals such as local and global Ca2+ elevations and also Ca2+ …

Capacitation is defined as a series of events that render boar sperm competent to fertilize,
either in vivo or in vitro. Moreover, preliminary stages of cryopreservation of spermatozoa …