Significant progress has recently been made in our understanding of animal regenerative
biology, spurred on by the use of a wider range of model organisms and an increasing …

The topipotency of the germline is the full manifestation of the pluri-and multipotency of
embryonic and adult stem cells, thus the germline and stem cells must share common …

Mammals have extremely limited regenerative capabilities; however, axolotls are profoundly
regenerative and can replace entire limbs. The mechanisms underlying limb regeneration …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Decapitated Hydra regenerate their heads via morphallaxis, ie, without significant
contributions made by cell proliferation or interstitial stem cells. Indeed, Hydra depleted of …

In plants and in the nematode Caenorhabditis elegans, an RNAi signal can trigger gene
silencing in cells distant from the site where silencing is initiated. In plants, this signal is …

The germline of multicellular animals is segregated from somatic tissues, which is an
essential developmental process for the next generation. Although certain ecdysozoans and …

The discovery of RNA interference (RNAi), the process of sequence-specific gene silencing
initiated by double-stranded RNA (dsRNA), has broadened our understanding of gene …

Canonical RNAi, one of the so-called RNA-silencing mechanisms, is defined as sequence-
specific RNA degradation induced by long double-stranded RNA (dsRNA). RNAi occurs in …

The discovery of Hydra regeneration by Abraham Trembley in 1744 promoted much
scientific curiosity thanks to his clever design of experimental strategies away from the …