Chemokines and cytokines are critical for initiating and coordinating the organized and
sequential recruitment and activation of cells into Mycobacterium tuberculosis-infected …

Tuberculosis (TB) in humans is caused by Mycobacterium tuberculosis (Mtb). It is estimated
that 70 million children (< 15 years) are currently infected with Mtb, with 1.2 million each year …

Objectives New tests are needed to overcome the limitations of existing immunodiagnostic
tests for tuberculosis (TB) infection, including their inability to differentiate between active TB …

The formation and maintenance of granulomas is central to the host response to
Mycobacterium tuberculosis (Mtb) infection. It is widely accepted that the lungs of patients …

Background: The early secreted antigenic target 6-kDa protein (ESAT-6) of Mycobacterium
tuberculosis (Mtb) not only acts as a key player for virulence but also exhibits a strong …

Introduction As studies of biomarkers of tuberculosis (TB) disease provide hope for a simple,
point-of-care test, we aimed to synthesize evidence on biomarkers for diagnosis of TB in …

Background: Interferon-gamma release assays (IGRA) are well-established
immunodiagnostic tests for tuberculosis (TB) in adults. In children these tests are associated …

The diagnosis of pediatric tuberculosis (TB) poses a challenge for clinical teams worldwide.
TB-mediated changes in the expression of host genes in the peripheral blood can serve as …

Objective Accurate and timely diagnosis of tuberculosis (TB) is essential to control the global
pandemic. Currently available immunodiagnostic tests cannot discriminate between latent …

Pediatric tuberculosis (TB) is challenging to diagnose, confirmed by growth of
Mycobacterium tuberculosis at best in 40% of cases. The WHO has assigned high priority to …