The protein kinases regulate cellular functions such as transcription, translation,
proliferation, growth and survival by the process of phosphorylation. Over activation of …

The 70 kDa heat shock proteins (HSP70s) are a group of highly conserved and inducible
heat shock proteins. One of the main functions of HSP70s is to act as molecular chaperones …

Background: Control of ER-mitochondrial Ca 2+ fluxes is a critical checkpoint to determine
cell fate under stress. The 75-kDa glucose-regulated protein (GRP75) is a key tether protein …

Abstract Mortalin/mthsp70 (HSPA9) is a stress chaperone enriched in many cancers that has
been implicated in carcinogenesis by promoting cell proliferation and survival. In this study …

Cancer is one of the leading causes of death worldwide, accounting for nearly 10 million
deaths in 2020. Therefore, cancer therapy is a priority research field to explore the biology of …

Mortalin (GRP75, HSPA9A), a heat shock protein (HSP), regulates a wide range of cellular
processes, including cell survival, growth, and metabolism. The regulatory functions of …

Background Cathelicidins are a major group of natural antimicrobial peptides which play
essential roles in regulating host defense and immunity. In addition to the antimicrobial and …

Optic neuropathies such as glaucoma occur when retinal ganglion cells (RGCs) in the eye
are injured. Strong evidence suggests mesenchymal stem cells (MSCs) could be a potential …

Background Chemoresistance remains a major treatment obstacle in multiple myeloma
(MM). Novel new therapies are thus in need. Transient Receptor Potential Vanilloid type 1 …

Previously, we showed that activation of the spinal CXCL9, 10/CXCR3 pathway mediated
bone cancer pain (BCP) in rats. However, the cellular mechanism involved is poorly …