Despite decades of study, subarachnoid hemorrhage (SAH) continues to be a serious and
significant health problem in the United States and worldwide. The mechanisms contributing …

Growing evidences suggest that stroke is a systemic disease affecting many organ systems
beyond the brain. Stroke-related systemic inflammatory response and immune …

Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating disease, which mainly
caused by the rupture of an intracranial aneurysm. Clinical trials have demonstrated that …

Background Early brain injury (EBI) following aneurysmal subarachnoid hemorrhage (SAH)
is an important predictor of poor functional outcome, yet the underlying mechanism is not …

Aneurysmal subarachnoid hemorrhage (aSAH) is one of the most severe neurological
disorders, with a high mortality rate and severe disabling functional sequelae. Systemic …

Inflammatory changes have been postulated to contribute to secondary brain injury after
aneurysmal subarachnoid hemorrhage (SAH). In human specimens after SAH as well as in …

Subarachnoid hemorrhage (SAH) is an important cause of stroke mortality and morbidity,
especially in the young stroke population. Recent evidences indicate that neuroinflammation …

Objective To examine the literature on risk factors for cerebral vasospasm (CV), one of the
most serious complications following aneurysmal subarachnoid hemorrhage (SAH), with …

Hydrocephalus is a common complication of aneurysmal subarachnoid hemorrhage (aSAH)
and reportedly contributes to poor neurological outcomes. In this review, we summarize the …

Background Translocation of high-mobility group box 1 (HMGB1) from nucleus could trigger
inflammation. Extracellular HMGB1 up-regulates inflammatory response in sepsis as a late …