The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

Dendritic cells (DCs) are a diverse group of specialized antigen-presenting cells with key
roles in the initiation and regulation of innate and adaptive immune responses. As such …

Dysregulation of the Notch signaling pathway, which is highly conserved across species,
can drive aberrant epigenetic modification, transcription, and translation. Defective gene …

At the interface between the innate and adaptive immune system, dendritic cells (DCs) play
key roles in tumour immunity and hold a hitherto unrealized potential for cancer …

High-dimensional approaches have revealed heterogeneity amongst dendritic cells (DCs),
including a population of transitional DCs (tDCs) in mice and humans. However, the origin …

Dendritic cells (DCs) are a unique class of immune cells that act as a bridge between innate
and adaptive immunity. The discovery of DCs by Cohen and Steinman in 1973 laid the …

Dendritic cells (DCs) secrete vast quantities of exosomes termed as dexosomes.
Dexosomes are symmetric nanoscale heat-stable vesicles that consist of a lipid bilayer …

Type 1 conventional dendritic cells (cDC1s) are typically thought to be dysregulated
secondarily to invasive cancer. Here, we report that cDC1 dysfunction instead develops in …

The formation of mammalian dendritic cells (DCs) is controlled by multiple hematopoietic
transcription factors, including IRF8. Loss of IRF8 exerts a differential effect on DC subsets …

Simple Summary Cancer immunotherapy is currently focused mainly on the enhancement of
the effector function of T cells. However, dendritic cells (DCs) are needed to prime T cells …