Therapeutic peptides: current applications and future directions

L Wang, N Wang, W Zhang, X Cheng, Z Yan… - Signal transduction and …, 2022 - nature.com
Peptide drug development has made great progress in the last decade thanks to new
production, modification, and analytic technologies. Peptides have been produced and …

In silico T cell epitope identification for SARS-CoV-2: Progress and perspectives

MS Sohail, SF Ahmed, AA Quadeer… - Advanced drug delivery …, 2021 - Elsevier
Growing evidence suggests that T cells may play a critical role in combating severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Hence, COVID-19 vaccines that can …

Identification of immunodominant linear epitopes from SARS-CoV-2 patient plasma

L Farrera-Soler, JP Daguer, S Barluenga, O Vadas… - PloS one, 2020 - journals.plos.org
A novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) is the source of a
current pandemic (COVID-19) with devastating consequences in public health and …

Computationally optimized SARS-CoV-2 MHC class I and II vaccine formulations predicted to target human haplotype distributions

G Liu, B Carter, T Bricken, S Jain, M Viard… - Cell systems, 2020 - cell.com
We present a combinatorial machine learning method to evaluate and optimize peptide
vaccine formulations for SARS-CoV-2. Our approach optimizes the presentation likelihood of …

[HTML][HTML] Immunoinformatics and molecular modeling approach to design universal multi-epitope vaccine for SARS-CoV-2

MT Khan, MJ Islam, A Parihar, R Islam, TJ Jerin… - Informatics in medicine …, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmittable
and pathogenic human coronavirus that caused a pandemic situation of acute respiratory …

Current and prospective computational approaches and challenges for developing COVID-19 vaccines

W Hwang, W Lei, NM Katritsis, M MacMahon… - Advanced drug delivery …, 2021 - Elsevier
Abstract SARS-CoV-2, which causes COVID-19, was first identified in humans in late 2019
and is a coronavirus which is zoonotic in origin. As it spread around the world there has …

Immunoinformatics design of multivalent epitope vaccine against monkeypox virus and its variants using membrane-bound, enveloped, and extracellular proteins as …

M Waqas, S Aziz, P Liò, Y Khan, A Ali, A Iqbal… - Frontiers in …, 2023 - frontiersin.org
Introduction The current monkeypox (MPX) outbreak, caused by the monkeypox virus
(MPXV), has turned into a global concern, with over 59,000 infection cases and 23 deaths …

Vaccinomics: A future avenue for vaccine development against emerging pathogens

J de la Fuente, M Contreras - Expert Review of Vaccines, 2021 - Taylor & Francis
Introduction Vaccines are a major achievement in medical sciences, but the development of
more effective vaccines against infectious diseases is essential for prevention and control of …

Peptide-based vaccines and therapeutics for COVID-19

PV Bagwe, PV Bagwe, SS Ponugoti… - International Journal of …, 2022 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been prevalent in the
humans since 2019 and has given rise to a pandemic situation. With the discovery and …

In silico and in vivo evaluation of SARS-CoV-2 predicted epitopes-based candidate vaccine

MM Shehata, SH Mahmoud, M Tarek… - Molecules, 2021 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2, the causative agent of
coronavirus disease (COVID-19)) has caused relatively high mortality rates in humans …