Targeting cervical cancer stem cells by phytochemicals

T Tripathi, J Yadav, D Janjua… - Current Medicinal …, 2024 - benthamdirect.com
Cervical cancer (CaCx) poses a significant global health challenge, ranking as the fourth
most common cancer among women worldwide. Despite the emergence of advanced …

Targeting the mTOR Pathway in Hepatocellular Carcinoma: The Therapeutic Potential of Natural Products

G Chen, Y Zhang, Y Zhou, H Luo… - Journal of Inflammation …, 2024 - Taylor & Francis
Despite advancements in cancer treatment through surgery and drugs, hepatocellular
carcinoma (HCC) remains a significant challenge, as reflected by its low survival rates. The …

Ovatodiolide induces autophagy-mediated cell death through the p62-Keap1-Nrf2 signaling pathway in chronic myeloid leukemia cells

Q Xia, J Xie, J Zhang, L Zhang, Y Zhou, B Zhu… - Chemico-Biological …, 2024 - Elsevier
Ovatodiolide is a macrocyclic diterpenoid compound with various biological activities that
displays considerable anticancer potential in different tumor models. However, the …

In vitro and in vivo anti-colorectal cancer effect of the newly synthesized sericin/propolis/fluorouracil nanoplatform through modulation of PI3K/AKT/mTOR pathway

SE Diab, NA Tayea, BH Elwakil, SS Elshewemi… - Scientific Reports, 2024 - nature.com
The present work aimed to assess the potential effect of sericin/propolis/fluorouracil
nanoformula against colorectal cancer (CRC)(the fourth most common cause of cancer …

[HTML][HTML] Targeting regulated cell death (RCD) with naturally derived sesquiterpene lactones in cancer therapy

C Xu, S Wen, X Du, X Zou, ELH Leung, G Zhou… - Pharmacological …, 2024 - Elsevier
Regulated cell death (RCD) is a type of cell death modulated by specific signal transduction
pathways. Currently, known RCD types include apoptosis, autophagy, ferroptosis …

Targeting the Neuropilin-1 receptor with Ovatodiolide and progress in using periodontal ligament organoids for COVID-19 research and therapy

MS Hsieh, MY Chen, YS Chang, CS Huang, TN Hsu… - Life Sciences, 2024 - Elsevier
The discovery of SARS-CoV-2 RNA in the periodontal tissues of patients who tested positive
for COVID-19, 24 days post the initial symptom onset, indicates the oral cavity could serve as …

Ovatodiolide inhibits endometrial cancer stemness via reactive oxygen species-mediated DNA damage and cell cycle arrest

CY Chen, YZ Ye, YH Huang, YM Tzeng… - Chemico-Biological …, 2024 - Elsevier
Endometrial cancer (EC) is a common gynecological cancer worldwide, often associated
with a poor prognosis after recurrence or metastasis. Ovatodiolide (OVA) is a macrocyclic …

[HTML][HTML] Ribosome biogenesis: A central player in liver diseases

W Luo, J Zhou, Y Yan, X Xu - Genes & Diseases, 2025 - Elsevier
Ribosome biogenesis is a multi-step process that initiates within the nucleolus, terminates in
the cytoplasm, and determines the rate of protein synthesis. Ribosome biogenesis is …

Therapeutic targeting of hepatocellular carcinoma cells with antrocinol, a novel, dual-specificity, small-molecule inhibitor of the KRAS and ERK oncogenic signaling …

CH Hsu, PW Weng, MY Chen, CT Yeh… - Chemico-Biological …, 2023 - Elsevier
Until recently, sorafenib has been the only treatment approved by the US Food and Drug
Administration for patients with advanced hepatocellular carcinoma (HCC). Some patients …

Ellagic acid inhibits tumor growth and potentiates the therapeutic efficacy of sorafenib in hepatocellular carcinoma

Z Tan, X Li, X Chen, L Wang, B Chen, S Ren, M Zhao - Heliyon, 2024 - cell.com
Background Sorafenib is a classic molecular targeted drug approved for hepatocellular
carcinoma (HCC) therapy. However, a poor response rate and increasing resistance to …