Aminoglycoside antibiotics were among the first antibiotics discovered and used clinically.
Although they have never completely fallen out of favor, their importance has waned due to …

Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

The 30S ribosomal subunit has two primary functions in protein synthesis. It discriminates
against aminoacyl transfer RNAs that do not match the codon of messenger RNA, thereby …

We describe the crystal structure of the complete Thermus thermophilus 70 S ribosome
containing bound messenger RNA and transfer RNAs (tRNAs) at 5.5 angstrom resolution …

The publication of crystal structures of the 50S and 30S ribosomal subunits and the intact
70S ribosome is revolutionizing our understanding of protein synthesis. This review is an …

Crystal structures of the 30 S ribosomal subunit in complex with messenger RNA and
cognate transfer RNA in the A site, both in the presence and absence of the antibiotic …

During protein synthesis, the ribosome accurately selects transfer RNAs (tRNAs) in
accordance with the messenger RNA (mRNA) triplet in the decoding centre. tRNA selection …

Repair of DNA damage is essential for maintaining genome integrity, and repair deficiencies
in mammals are associated with cancer, neurological disease and developmental defects …

Many clinically useful antibiotics exert their antimicrobial effects by blocking protein
synthesis on the bacterial ribosome. The structure of the ribosome has recently been …

The recently discovered functions of RNA dramatically expand the cellular roles for this
macromolecule. RNA can no longer be viewed as a passive element, working simply as an …