Telomeres are nucleoprotein structures that cap the ends of the linear eukaryotic
chromosomes and thereby protect their stability and integrity. Telomeres play central roles in …

As average life span and elderly people prevalence in the western world population is
gradually increasing, the incidence of age-related diseases such as cancer, heart diseases …

Maintenance of a minimal telomere length is essential to prevent cellular senescence. When
critically short telomeres arise in the absence of telomerase, they can be repaired by …

The budding yeast Saccharomyces cerevisiae is a highly advanced model system for
studying genetics, cell biology and systems biology. Over the past decade, the application of …

Cancer cells achieve immortality by employing either homology-directed repair (HDR) or the
telomerase enzyme to maintain telomeres. ALT (alternative lengthening of telomeres) refers …

ATP-dependent chromatin remodeling is involved in all DNA transactions and is linked to
numerous human diseases. We explored functions of chromatin remodelers during cellular …

In cells lacking telomerase, telomeres gradually shorten during each cell division to reach a
critically short length, permanently activate the DNA damage checkpoint, and trigger …

In the absence of telomerase, telomeres progressively shorten with every round of DNA
replication, leading to replicative senescence. In telomerase-deficient Saccharomyces …

The Caenorhabditis elegans model has greatly contributed to the understanding of the role
of G-quadruplexes in genomic instability. The GGCTTA repeats of the C. elegans telomeres …

In eukaryotes, telomeres cap chromosome ends to maintain genomic stability. Failure to
maintain telomeres leads to their progressive erosion and eventually triggers replicative …