This article is part of a Minifocus on Ubiquitin. For further reading, please see related
articles: ʻUbiquitin and SUMO in DNA repair at a glanceʼ by Helle D. Ulrich (J. Cell Sci …

The endoplasmic reticulum (ER) is an essential organelle involved in many cellular
functions including protein folding and secretion, lipid biosynthesis, and calcium …

Recruitment of immune cells to the site of inflammation by the chemokine CCL1 is important
in the pathology of inflammatory diseases. Here, we examined the role of CCL1 in …

Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

The Hsp90/Hsp70-based chaperone machinery plays a well-established role in signaling
protein function, trafficking and turnover. A number of recent observations also support the …

The CYP3A subfamily, which includes isoforms CYP3A4, CYP3A5, and CYP3A7 in humans,
plays important roles in the metabolism of various endogenous and exogenous substances …

Abstract Tryptophan 2, 3-dioxygenase (TDO) and indoleamine 2, 3-dioxygenase (IDO) play
a central role in tryptophan metabolism and are involved in many cellular and disease …

Deciphering the inositol-requiring enzyme 1 (IRE1) signaling pathway is fundamentally
important for understanding the unfolded protein response (UPR). The ubiquitination of …

As per the requirement of metabolism and fitness, normal cellular functions are controlled by
several proteins, and their interactive molecular and signaling events at multiple levels …

The hepatic endoplasmic reticulum (ER)-anchored cytochromes P450 (P450s) are mixed-
function oxidases engaged in the biotransformation of physiologically relevant endobiotics …