Targeting the NLRP3 inflammasome in cardiovascular diseases

S Toldo, E Mezzaroma, LF Buckley, N Potere… - Pharmacology & …, 2022 - Elsevier
The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …

Interleukin-1 and the inflammasome as therapeutic targets in cardiovascular disease

A Abbate, S Toldo, C Marchetti, J Kron… - Circulation …, 2020 - Am Heart Assoc
The intracellular sensing protein termed NLRP3 (for NACHT, LRR, and PYD domains-
containing protein 3) forms a macromolecular structure called the NLRP3 inflammasome …

Mitochondria in acute myocardial infarction and cardioprotection

CJA Ramachandra, S Hernandez-Resendiz… - …, 2020 - thelancet.com
Acute myocardial infarction (AMI) and the heart failure (HF) that often follows are among the
leading causes of death and disability worldwide. As such, new treatments are needed to …

Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation

C Yao, T Veleva, L Scott Jr, S Cao, L Li, G Chen… - Circulation, 2018 - Am Heart Assoc
Background: Atrial fibrillation (AF) is frequently associated with enhanced inflammatory
response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome …

The NLRP3 inflammasome in acute myocardial infarction

S Toldo, A Abbate - Nature Reviews Cardiology, 2018 - nature.com
The heart is extremely sensitive to ischaemic injury. During an acute myocardial infarction
(AMI) event, the injury is initially caused by reduced blood supply to the tissues, which is …

The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases

S Toldo, A Abbate - Nature Reviews Cardiology, 2024 - nature.com
An intense, stereotyped inflammatory response occurs in response to ischaemic and non-
ischaemic injury to the myocardium. The NACHT, LRR and PYD domains-containing protein …

Anti-inflammatory action of statins in cardiovascular disease: the role of inflammasome and toll-like receptor pathways

K Koushki, SK Shahbaz, K Mashayekhi… - Clinical reviews in …, 2021 - Springer
Atherosclerosis is one type of cardiovascular disease (CVD) in which activation of the
NLRP3 inflammasome and toll-like receptor (TLR) pathways is implicated. One of the most …

Focus on the Role of NLRP3 Inflammasome in Diseases

R Fusco, R Siracusa, T Genovese… - International journal of …, 2020 - mdpi.com
Inflammation is a protective reaction activated in response to detrimental stimuli, such as
dead cells, irritants or pathogens, by the evolutionarily conserved immune system and is …

Inflammasome, pyroptosis, and cytokines in myocardial ischemia-reperfusion injury

S Toldo, AG Mauro, Z Cutter… - American Journal of …, 2018 - journals.physiology.org
Myocardial ischemia-reperfusion injury induces a sterile inflammatory response, leading to
further injury that contributes to the final infarct size. Locally released danger-associated …

The role of inflammasomes in human diseases and their potential as therapeutic targets

J Yao, K Sterling, Z Wang, Y Zhang… - Signal Transduction and …, 2024 - nature.com
Inflammasomes are large protein complexes that play a major role in sensing inflammatory
signals and triggering the innate immune response. Each inflammasome complex has three …