[HTML][HTML] Isoniazid metabolism and hepatotoxicity

P Wang, K Pradhan, X Zhong, X Ma - Acta pharmaceutica sinica B, 2016 - Elsevier
Isoniazid (INH) is highly effective for the management of tuberculosis. However, it can cause
liver injury and even liver failure. INH metabolism has been thought to be associated with …

Cytochrome P450-mediated metabolism in the human gut wall

K Thelen, JB Dressman - Journal of pharmacy and …, 2009 - academic.oup.com
Objective Although the human small intestine serves primarily as an absorptive organ for
nutrients and water, it also has the ability to metabolise drugs. Interest in the small intestine …

Contribution of genetic polymorphisms in human health

P Chiarella, P Capone, R Sisto - International Journal of Environmental …, 2023 - mdpi.com
Human health is influenced by various factors; these include genetic inheritance, behavioral
lifestyle, socioeconomic and environmental conditions, and public access to care and …

Tissue-specific mRNA expression profiles of human phase I metabolizing enzymes except for cytochrome P450 and phase II metabolizing enzymes

M Nishimura, S Naito - Drug metabolism and pharmacokinetics, 2006 - jstage.jst.go.jp
Pairs of forward and reverse primers and TaqMan probes specific to each of 52 human
phase I metabolizing enzymes (alcohol dehydrogenase, aldehyde dehydrogenase …

Hazardous air pollutants and asthma.

GD Leikauf - Environmental Health Perspectives, 2002 - ehp.niehs.nih.gov
Asthma has a high prevalence in the United States, and persons with asthma may be at
added risk from the adverse effects of hazardous air pollutants (HAPs). Complex mixtures …

Metabolism: A Bottleneck in In Vitro Toxicological Test Development: The Report and Recommendations of ECVAM Workshop 54

S Coecke, H Ahr, BJ Blaauboer… - Alternatives to …, 2006 - journals.sagepub.com
This is the 54th report of a series of workshops organised by the European Centre for the
Validation of Alternative Methods (ECVAM). The main objective of ECVAM, as defined in …

N-acetyltransferase 2 genetic polymorphism: effects of carcinogen and haplotype on urinary bladder cancer risk

DW Hein - Oncogene, 2006 - nature.com
A role for the N-acetyltransferase 2 (NAT2) genetic polymorphism in cancer risk has been
the subject of numerous studies. Although comprehensive reviews of the NAT2 acetylation …

Drug metabolism and pharmacokinetics

MS Benedetti, R Whomsley, I Poggesi… - Drug metabolism …, 2009 - Taylor & Francis
In this article, aspects of absorption, distribution, metabolism, and excretion have been
described bearing in mind the pathogenesis of allergic diseases and their possible …

Xenobiotic-metabolizing enzymes in human lung

JY Zhang, Y Fen Wang, C Prakash - Current drug metabolism, 2006 - ingentaconnect.com
Human lung is a major target organ for all inhaled drugs, environmental toxicants and
carcinogens. Recent hypotheses suggesting a role for environmental toxicants in the …

Evaluation of a new molecular entity as a victim of metabolic drug-drug interactions—an industry perspective

T Bohnert, A Patel, I Templeton, Y Chen, C Lu… - Drug Metabolism and …, 2016 - Elsevier
Under the guidance of the International Consortium for Innovation and Quality in
Pharmaceutical Development (IQ), scientists from 20 pharmaceutical companies formed a …