Chemotherapy is one of the most established and effective treatments for almost all types of
cancer. However, the elevated toxicity due to the non-tumor-associated effects, development …

Biliary tract cancers (BTCs) are rare with poor prognosis. Due to the advent of genomic
sequencing, new data have emerged regarding the molecular makeup of this disease. To …

Trichostatin A (TSA), a natural derivative of dienohydroxamic acid derived from a fungal
metabolite, exhibits various biological activities. It exerts antidiabetic activity and reverses …

Cholangiocarcinoma (CCA) is a highly invasive and metastatic form of carcinoma with bleak
prognosis due to limited therapies, frequent relapse, and chemotherapy resistance. There is …

Cisplatin (CP) is a broad-spectrum antineoplastic agent, used to treat many different types of
malignancies due to its high efficacy and low cost. However, its use is largely limited by …

Epigenetic modifications such as histone modification play an important role in
tumorigenesis. There are several evidence that histone deacetylases (HDACs) play a key …

Cisplatin (CP) is an effective chemotherapeutic agent widely used in the treatment of various
solid tumours. However, CP nephrotoxicity is an important limitation for CP use; currently …

Epigenetic therapy is a novel tumor therapeutic method and refers to the targeting of the
aberrant epigenetic modifications presumably at cancer-related genes by chemicals which …

Simple Summary Biliary tract cancer (BTC) is a rare disease with dismal outcomes.
Therefore, the investigation of new therapeutic targets is urgently required. In this study, we …

Cholangiocarcinoma is a devastating malignancy with fatal complications that exhibits low
response and resistance to chemotherapy. Here, we evaluated the anticancer effects of …