The Major Histocompatibility Complex (MHC) locus encodes classical MHC class I and MHC
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …

T cells are a critical part of the adaptive immune system that are able to distinguish between
healthy and unhealthy cells. Upon recognition of protein fragments (peptides), activated T …

Adoptive cell therapy using engineered T cell receptors (TCRs) is a promising approach for
targeting cancer antigens, but tumor-reactive TCRs are often weakly responsive to their …

TCR-signaling strength generally correlates with peptide-MHC binding affinity; however,
exceptions exist. We find high-affinity, yet non-stimulatory, interactions occur with high …

The immune system can mount T cell responses against tumors; however, the antigen
specificities of tumor-infiltrating lymphocytes (TILs) are not well understood. We used yeast …

Introduction Predicting the binding specificity of T Cell Receptors (TCR) to MHC-peptide
complexes (pMHCs) is essential for the development of repertoire-based biomarkers. This …

In order to survey a universe of major histocompatibility complex (MHC)-presented peptide
antigens whose numbers greatly exceed the diversity of the T cell repertoire, T cell receptors …

TCR-pMHC interactions initiate adaptive immune responses, but the mechanism of how
such interactions under force induce T cell signaling is unclear. We show that force prolongs …

T cell discrimination of self and non-self is predicated on αβ T cell receptor (TCR) co-
recognition of peptides presented by MHC molecules. Over the past 20 years, structurally …

T cell receptors (TCRs) are protein complexes formed by six different polypeptides. In most T
cells, TCRs are composed of αβ subunits displaying immunoglobulin-like variable domains …