Protein glycosylation involves the co-translational or post-translational addition of glycans to
proteins and is a crucial protein modification in health and disease. The aim of …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor patient
survival. Toward understanding the underlying molecular alterations that drive PDAC …

Facilitated by advances in the separation sciences, mass spectrometry and informatics,
glycoproteomics, the analysis of intact glycopeptides at scale, has recently matured enabling …

Site-specific characterization of glycosylation requires intact glycopeptide analysis, and
recent efforts have focused on how to best interrogate glycopeptides using tandem mass …

Protein glycosylation, a complex and heterogeneous post-translational modification that is
frequently dysregulated in disease, has been difficult to analyse at scale. Here we report a …

Many gene products exhibit great structural heterogeneity because of an array of
modifications. These modifications are not directly encoded in the genomic template but …

Glycans constitute the most complicated post-translational modification, modulating protein
activity in health and disease. However, structural annotation from tandem mass …

Core fucosylation of N-linked glycoproteins has been linked to the functions of glycoproteins
in physiological and pathological processes. However, quantitative characterization of core …

Heterogeneity of protein glycosylation poses great challenges for analysis that is key to
understand structure and function of glycoproteins. Resolving this conundrum requires …

Although genomic anomalies in glioblastoma (GBM) have been well studied for over a
decade, its 5-year survival rate remains lower than 5%. We seek to expand the molecular …