Reducing oxidative stress stands at the center of a prevention and control strategy for
mitigating cellular senescence and aging. Kidney disease is characterized by a premature …

Diabetes mellitus contributes greatly to morbidity, mortality, and overall health care costs. In
major part, these outcomes derive from the high incidence of progressive kidney dysfunction …

Fibrosis is the final common pathway leading to end-stage renal failure. By analyzing the
kidneys of patients and animal models with fibrosis, we observed a significant mitochondrial …

Mitochondrial biogenesis (MB) is the essential mechanism by which cells control the number
of mitochondria. Cells respond to different physiologic, metabolic, and pathologic changes …

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone
receptor superfamily of ligand-activated transcription factors. Accumulating evidence …

Chronic kidney disease (CKD) is becoming a global burden, despite recent advances in
management. CKD can begin in early life by so-called “developmental programming” or …

The transcriptional regulation of mitochondrial biogenesis by normal metabolic adaptation or
injury has been clarified over the past decade. Mitochondrial biogenesis and its attendant …

Previously, we have reported that Corni Fructus possessed hypoglycemic and
hypocholesterolemic effects in streptozotocin-induced type 1 diabetic rats and diet-induced …

Transforming growth factor-β (TGF-β)/Smad3 signaling has been shown to play important
roles in fibrotic and inflammatory diseases. However, the role of Smad3 in dyslipidemia and …

Liver ischemia-reperfusion injury (IRI) is a major complication of hemorrhagic shock, liver
transplantation, and other liver surgeries. It is one of the leading causes for post-surgery …