We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a
sample of~ 3 million individuals and identify 3,952 approximately uncorrelated genome …

The selection pressures that have shaped the evolution of complex traits in humans remain
largely unknown, and in some contexts highly contentious, perhaps above all where they …

Single nucleotide polymorphisms (SNPs) are the most abundant type of genomic variation
and the most accessible to genotype in large cohorts. However, they individually explain a …

Transcriptional regulation exhibits extensive robustness, but human genetics indicates
sensitivity to transcription factor (TF) dosage. Reconciling such observations requires …

Although the cohort-level accuracy of polygenic risk scores (PRSs)—estimates of genetic
value at the individual level—has been widely assessed, uncertainty in PRSs remains …

Primary biliary cholangitis (PBC) is a rare autoimmune disease of the liver affecting the small
bile ducts. From a genetic point of view, PBC is a complex trait and several genetic and …

Classical statistical genetics theory defines dominance as any deviation from a purely
additive, or dosage, effect of a genotype on a trait, which is known as the dominance …

While adoption studies have provided key insights into the influence of the familial
environment on IQ scores of adolescents and children, few have followed adopted offspring …

The quantitative geneticist WG ('Bill') Hill, awardee of the 2018 Darwin Medal of the Royal
Society and the 2019 Mendel Medal of the Genetics Society (United Kingdom), died on 17 …

Dominance heritability in complex traits has received increasing recognition. However, most
polygenic score (PGS) approaches do not incorporate non-additive effects. Here, we present …