Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …

Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …

Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

More than 80 years ago, the first Polycomb-related phenotype was identified in Drosophila
melanogaster. Later, a group of diverse genes collectively called Polycomb group (PcG) …

Cellular senescence is a highly stable cell cycle arrest that is elicited in response to different
stresses. By imposing a growth arrest, senescence limits the replication of old or damaged …

The accumulation of senescent cells can drive many age-associated phenotypes and
pathologies. Consequently, it has been proposed that removing senescent cells might …

Diagnosis and treatment of disease demand a sound understanding of the underlying
mechanisms, determining any Achilles' heel that can be targeted in effective therapies …

Aging is the major risk factor for cancer, cardiovascular disease, diabetes, and
neurodegenerative disorders. Although we are far from understanding the biological basis of …

Next-generation genomic sequencing has identified multiple novel molecular alterations in
cancer. Since the identification of DNA methylation and histone modification, it has become …

Globally, 50 million people live with dementia, with Alzheimer disease (AD) being
responsible for two-thirds of the total cases. As ageing is the main risk factor for dementia …