MCP-1: Function, regulation, and involvement in disease

S Singh, D Anshita, V Ravichandiran - International immunopharmacology, 2021 - Elsevier
Abstract MCP-1 (Monocyte chemoattractant protein-1), also known as Chemokine (CC-motif)
ligand 2 (CCL2), is from family of CC chemokines. It has a vital role in the process of …

CXCL8 in tumor biology and its implications for clinical translation

X Xiong, X Liao, S Qiu, H Xu, S Zhang… - Frontiers in molecular …, 2022 - frontiersin.org
The chemokine CXCL8 has been found to play an important role in tumor progression in
recent years. CXCL8 activates multiple intracellular signaling pathways by binding to its …

CCL2: an important mediator between tumor cells and host cells in tumor microenvironment

J Jin, J Lin, A Xu, J Lou, C Qian, X Li, Y Wang… - Frontiers in …, 2021 - frontiersin.org
Tumor microenvironment (TME) formation is a major cause of immunosuppression. The TME
consists of a considerable number of macrophages and stromal cells that have been …

MCP‑1 targeting: Shutting off an engine for tumor development

L Wang, J Lan, J Tang, N Luo - Oncology letters, 2022 - spandidos-publications.com
A large amount of research has proven that monocyte chemotactic protein‑1 (MCP‑1) is
associated with different types of disease, including autoimmune, metabolic and …

The Anticancer Effects and Therapeutic Potential of Kaempferol in Triple-Negative Breast Cancer

S Kaur, P Mendonca, KFA Soliman - Nutrients, 2024 - mdpi.com
Breast cancer is the second-leading cause of cancer death among women in the United
States. Triple-negative breast cancer (TNBC), a subtype of breast cancer, is an aggressive …

[HTML][HTML] IL-8 secreted by tumor associated macrophages contribute to lapatinib resistance in HER2-positive locally advanced breast cancer via activation of Src/STAT3 …

S Ahmed, HT Mohamed, N El-Husseiny… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Locally advanced breast cancer (LABC) is an aggressive disease characterized by late
clinical presentation, large tumor size, treatment resistance and low survival rate. Expression …

Pro-inflammatory and anti-inflammatory salivary cytokines in breast cancer: relationship with clinicopathological characteristics of the tumor

LV Bel'skaya, AI Loginova, EA Sarf - Current Issues in Molecular Biology, 2022 - mdpi.com
The aim of the work was to compare the salivary cytokine profile of breast cancer patients
with the clinicopathological characteristics of the tumor. The study included 113 patients with …

Assessing serum cytokine profiles in inflammatory breast cancer patients using Luminex® technology

M Bessaad, A Habel, MH Ahmed, W Xu, M Stayoussef… - Cytokine, 2023 - Elsevier
Background Inflammatory breast cancer (IBC), accounts for the majority of deaths associated
with breast tumors. Because this form is aggressive from its appearance and has a strong …

Proto-oncogene tyrosine-protein kinase SRC (Src) inhibition in microglia relieves neuroinflammation in neuropathic pain mouse models

Y Cai, J Xu, Q Cheng - Bioengineered, 2021 - Taylor & Francis
Chronic neuroinflammation is an important factor in the development of neuropathic pain
(NP). Excess microglia activation releases a mass of pro-inflammatory cytokines during …

[HTML][HTML] Healing mechanism of diabetic foot ulcers using single-cell RNA-sequencing

Z Wang, D Wei, S Li, Q Tang, G Lu, S Gu… - Annals of …, 2023 - ncbi.nlm.nih.gov
Background Diabetic foot ulcer (DFU) is one of the common and severe complications in
diabetic patients, mainly caused by the interaction of various factors such as peripheral …