ADME and toxicity considerations for tramadol: from basic research to clinical implications

M Doostmohammadi, HR Rahimi - Expert Opinion on Drug …, 2020 - Taylor & Francis
Introduction Tramadol is widely being used in chronic pain management for improving
patients' life quality and reducing trauma. Although it is listed in several medicinal …

Toxicology of tramadol following chronic exposure based on metabolomics of the cerebrum in mice

W Xia, G Liu, Z Shao, E Xu, H Yuan, J Liu, L Gao - Scientific reports, 2020 - nature.com
Tramadol is an opioid used as an analgesic for treating moderate or severe pain. The long-
term use of tramadol can induce several adverse effects. The toxicological mechanism of …

[HTML][HTML] Exploring the association between air pollution and the incidence of liver cancers

X Wu, X Zhang, X Yu, H Liang, S Tang… - … and Environmental Safety, 2025 - Elsevier
Liver cancer, namely hepatocellular carcinoma (HCC), is a major global health concern
deeply influenced by environmental factors. Air pollutants emerged as significant …

Genotoxic and mutagenic potential of 7-methylxanthine: an investigational drug molecule for the treatment of myopia

H Singh, H Singh, S Sharma, H Kaur… - Drug and Chemical …, 2024 - Taylor & Francis
Methylxanthine (7-MX, CAS No. 552-62-5, purity 99.46%) is the first orally administered drug
candidate, which showed anti-myopic activity in different pre-clinical studies. In the present …

[PDF][PDF] Protective effect of Costus Speciosus rhizome extract against cytotoxicity induced by tramadol in mice

HM Daabo - Biointerface Research in Applied Chemistry, 2021 - researchgate.net
Tramadol is a centrally acting analgesic generally used to treat moderate to severe pain.
This study was designed to evaluate the protective effect of Costus speciosus rhizome …

Protective effects of barley and wheat grasses on nephrotoxicity in rats and some biochemical parameters induced by tramadol

HSE Eldamaty - Egyptian Journal of Nutrition and Health, 2020 - journals.ekb.eg
The present study was conducted to evaluate the protective effects of barley and wheat
grasses against tramadol induced nephrotoxicity, biochemical changes as well as oxidative …

[PDF][PDF] Cytotoxic and genotoxic effects of the ethanolic extract from the rind of the fruit of Sterculia striata St. Hil. & Naudin Efeitos citotóxicos e genotóxicos do extrato …

MV Cosme, S e Melo, AM Benko-Iseppon, JSS Nery… - Braz J Hea …, 2021 - academia.edu
The species Sterculia striata A. St. Hil. & Naudin has been used by the population in food
and in the treatment of skin conditions, mainly for the treatment of boils. Recently, for this …

Cytogenesis Effects on Sub-chronic administration of Cypermethrin in Albino Wistar Rats by different Mammalian Bio-assays

S Kalra, GK Sangha - Pesticide Research Journal, 2021 - indianjournals.com
The cytogenotoxic effects of cypermethrin on bone marrow cells and lymphocytes of Wistar
rats are reported. During four weeks of experimentation, cypermethrin admistration at 1/25th …

[PDF][PDF] Mecanismos de genotoxicidade in vivo do tramadol: uma revisão bibliográfica

P Couto, RJ Dinis-Oliveira, J Faria… - … Internacional da Rede …, 2022 - revsalus.com
POSTER 30 Etilenoglicol POSTER 31 Mecanismos de genotoxicidade in vivo do tramadol:
uma revisão bibliográfica Page 1 7 6 Introdução: O etilenoglicol é um álcool utilizado na …

[PDF][PDF] Estudo de biomarcadores de genotoxicidade e nefrotoxicidade decorrentes da exposição a doses terapêuticas de tramadol

M Silva, RJ Dinis-Oliveira, J Faria… - … Científica Internacional da …, 2022 - revsalus.com
Introdução: O tramadol é o opioide sintético mais prescrito mundialmente. Este fármaco tem
uma ação central analgésica [1], com um mecanismo de ação duplo e sinérgico, atuando …