Tools for the microbiome: nano and beyond

JS Biteen, PC Blainey, ZG Cardon, M Chun… - ACS …, 2016 - ACS Publications
The microbiome presents great opportunities for understanding and improving the world
around us and elucidating the interactions that compose it. The microbiome also poses …

Teleosts as model organisms to understand host-microbe interactions

EA Lescak, KC Milligan-Myhre - Journal of bacteriology, 2017 - Am Soc Microbiol
Host-microbe interactions are influenced by complex host genetics and environment.
Studies across animal taxa have aided our understanding of how intestinal microbiota …

A conserved bacterial protein induces pancreatic beta cell expansion during zebrafish development

JH Hill, EA Franzosa, C Huttenhower, K Guillemin - Elife, 2016 - elifesciences.org
Resident microbes play important roles in the development of the gastrointestinal tract, but
their influence on other digestive organs is less well explored. Using the gnotobiotic …

A mucin-regulated adhesin determines the spatial organization and inflammatory character of a bacterial symbiont in the vertebrate gut

TJ Smith, D Sundarraman, E Melancon, L Desban… - Cell Host & Microbe, 2023 - cell.com
In a healthy gut, microbes are often aggregated with host mucus, yet the molecular basis for
this organization and its impact on intestinal health are unclear. Mucus is a viscous physical …

Modernized tools for streamlined genetic manipulation and comparative study of wild and diverse proteobacterial lineages

TJ Wiles, ES Wall, BH Schlomann, EA Hay… - MBio, 2018 - Am Soc Microbiol
Correlating the presence of bacteria and the genes they carry with aspects of plant and
animal biology is rapidly outpacing the functional characterization of naturally occurring …

A bacterial immunomodulatory protein with lipocalin-like domains facilitates host–bacteria mutualism in larval zebrafish

AS Rolig, EG Sweeney, LE Kaye, MD DeSantis… - Elife, 2018 - elifesciences.org
Stable mutualism between a host and its resident bacteria requires a moderated immune
response to control bacterial population size without eliciting excessive inflammation that …

Spatiotemporally heterogeneous population dynamics of gut bacteria inferred from fecal time series data

H Inamine, SP Ellner, PD Newell, Y Luo, N Buchon… - MBio, 2018 - Am Soc Microbiol
ABSTRACT A priority in gut microbiome research is to develop methods to investigate
ecological processes shaping microbial populations in the host from readily accessible data …

Microbial species coexistence depends on the host environment

P Deines, K Hammerschmidt, TCG Bosch - MBio, 2020 - Am Soc Microbiol
Organisms and their resident microbial communities form a complex and mostly stable
ecosystem. It is known that the specific composition and abundance of certain bacterial …

The Vibrio type VI secretion system induces intestinal macrophage redistribution and enhanced intestinal motility

JS Ngo, P Amitabh, JG Sokoloff, C Trinh, TJ Wiles… - MBio, 2025 - journals.asm.org
Intestinal microbes, whether resident or transient, influence the physiology of their hosts,
altering both the chemical and the physical characteristics of the gut. An example of the latter …

Gut bacterial aggregates as living gels

BH Schlomann, R Parthasarathy - Elife, 2021 - elifesciences.org
The spatial organization of gut microbiota influences both microbial abundances and host-
microbe interactions, but the underlying rules relating bacterial dynamics to large-scale …