SOX9 in organogenesis: shared and unique transcriptional functions
The transcription factor SOX9 is essential for the development of multiple organs including
bone, testis, heart, lung, pancreas, intestine and nervous system. Mutations in the human …
bone, testis, heart, lung, pancreas, intestine and nervous system. Mutations in the human …
How to manage without a Y chromosome
M Schartl, DK Lamatsch - Proceedings of the National …, 2023 - National Acad Sciences
The mammalian Y chromosome is genetically degenerated and small compared with its
counterpart, the X chromosome. The X and Y evolved approximately 180 Mya from an …
counterpart, the X chromosome. The X and Y evolved approximately 180 Mya from an …
FOXL2 interaction with different binding partners regulates the dynamics of ovarian development
The transcription factor FOXL2 is required in ovarian somatic cells for female fertility.
Differential timing of Foxl2 deletion, in embryonic versus adult mouse ovary, leads to …
Differential timing of Foxl2 deletion, in embryonic versus adult mouse ovary, leads to …
46, XY disorders of sexual development
The 46, XY differences of sex development (46, XY DSD) can result either from decreased
synthesis of testosterone and/or DHT or from impairment of androgen action. 46, XY DSD …
synthesis of testosterone and/or DHT or from impairment of androgen action. 46, XY DSD …
Clinical utility of early rapid genome sequencing in the evaluation of patients with differences of sex development
A Aekka, AG Weisman, J Papadakis… - American Journal of …, 2024 - Wiley Online Library
Establishing an early and accurate genetic diagnosis among patients with differences of sex
development (DSD) is crucial in guiding the complex medical and psychosocial care they …
development (DSD) is crucial in guiding the complex medical and psychosocial care they …
The use of in silico extreme pathway (ExPa) analysis to identify conserved reproductive transcriptional-regulatory networks in humans, mice, and zebrafish
D Hala - Systems Biology in Reproductive Medicine, 2023 - Taylor & Francis
Vertebrate sex determination and differentiation are coordinated by the activations and
maintenance of reproductive transcriptional-regulatory networks (TRNs). There is …
maintenance of reproductive transcriptional-regulatory networks (TRNs). There is …
FOXL2 interaction with different binding partners regulates the dynamics of granulosa cell differentiation across ovarian development
FOXL2 is a transcription factor essential for female fertility, expressed in somatic cells of the
ovary, notably granulosa cells. In the mouse, Foxl2 deletion leads to partial sex reversal …
ovary, notably granulosa cells. In the mouse, Foxl2 deletion leads to partial sex reversal …
[HTML][HTML] 46, XY Differences of Sexual Development
S Domenice, RL Batista, J Ivo, P Arnhold… - Endotext …, 2022 - ncbi.nlm.nih.gov
The 46, XY differences of sex development (46, XY DSD) can result either from decreased
synthesis of testosterone and/or DHT or from impairment of androgen action. 46, XY DSD …
synthesis of testosterone and/or DHT or from impairment of androgen action. 46, XY DSD …