DNA damage and repair in age-related inflammation
Genomic instability is an important driver of ageing. The accumulation of DNA damage is
believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction …
believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction …
Regulatory activities of transposable elements: from conflicts to benefits
Transposable elements (TEs) are a prolific source of tightly regulated, biochemically active
non-coding elements, such as transcription factor-binding sites and non-coding RNAs. Many …
non-coding elements, such as transcription factor-binding sites and non-coding RNAs. Many …
Epigenetically controlled tumor antigens derived from splice junctions between exons and transposable elements
M Burbage, A Rocañín-Arjó, B Baudon, YA Arribas… - Science …, 2023 - science.org
Oncogenesis often implicates epigenetic alterations, including derepression of transposable
elements (TEs) and defects in alternative splicing. Here, we explore the possibility that …
elements (TEs) and defects in alternative splicing. Here, we explore the possibility that …
Melatonin, a full service anti-cancer agent: inhibition of initiation, progression and metastasis
There is highly credible evidence that melatonin mitigates cancer at the initiation,
progression and metastasis phases. In many cases, the molecular mechanisms …
progression and metastasis phases. In many cases, the molecular mechanisms …
Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways
Stromal communication with cancer cells can influence treatment response. We show that
stromal and breast cancer (BrCa) cells utilize paracrine and juxtacrine signaling to drive …
stromal and breast cancer (BrCa) cells utilize paracrine and juxtacrine signaling to drive …
Restricting retrotransposons: a review
JL Goodier - Mobile DNA, 2016 - Springer
Retrotransposons have generated about 40% of the human genome. This review examines
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …
Regulation of single-strand annealing and its role in genome maintenance
R Bhargava, DO Onyango, JM Stark - Trends in Genetics, 2016 - cell.com
Single-strand annealing (SSA) is a DNA double-strand break (DSB) repair pathway that
uses homologous repeats to bridge DSB ends. SSA involving repeats that flank a single …
uses homologous repeats to bridge DSB ends. SSA involving repeats that flank a single …
Alu elements: know the SINEs
P Deininger - Genome biology, 2011 - Springer
Alu elements: know the SINEs | Genome Biology Skip to main content SpringerLink Account
Menu Find a journal Publish with us Track your research Search Cart 1.Home 2.Genome …
Menu Find a journal Publish with us Track your research Search Cart 1.Home 2.Genome …
Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements
M De Cecco, SW Criscione, EJ Peckham… - Aging cell, 2013 - Wiley Online Library
Replicative cellular senescence is an important tumor suppression mechanism and also
contributes to aging. Progression of both cancer and aging include significant epigenetic …
contributes to aging. Progression of both cancer and aging include significant epigenetic …