The suppressive efficacy of THZ1 depends on KRAS mutation subtype and is associated with super‐enhancer activity and the PI3K/AKT/mTOR signalling in …
L Huang, H Yang, K Chen, J Yuan, J Li… - Clinical and …, 2023 - Wiley Online Library
Background Inhibition of CDK7, a potent transcription regulator, may bring new hope for
treating pancreatic ductal adenocarcinoma (PDAC), which is featured by large genetic …
treating pancreatic ductal adenocarcinoma (PDAC), which is featured by large genetic …
Navigating glioblastoma complexity: the interplay of neurotransmitters and chromatin
J Romero-Reyes, ER Vázquez-Martínez… - Molecular Biology …, 2024 - Springer
Glioblastoma is the most aggressive brain cancer with an unfavorable prognosis for patient
survival. Glioma stem cells, a subpopulation of cancer cells, drive tumor initiation, self …
survival. Glioma stem cells, a subpopulation of cancer cells, drive tumor initiation, self …
[HTML][HTML] H2A. Z histone variants facilitate HDACi-dependent removal of H3. 3K27M mutant protein in pediatric high-grade glioma cells
KB Leszczynska, A Freitas-Huhtamäki, C Jayaprakash… - Cell reports, 2024 - cell.com
Diffuse intrinsic pontine gliomas (DIPGs) are deadly pediatric brain tumors, non-resectable
due to brainstem localization and diffusive growth. Over 80% of DIPGs harbor a mutation in …
due to brainstem localization and diffusive growth. Over 80% of DIPGs harbor a mutation in …
Long‐Term Administration of Omeprazole‐Induced Hypergastrinemia and Changed Glucose Homeostasis and Expression of Metabolism‐Related Genes
A Kabaliei, V Palchyk, O Izmailova… - BioMed Research …, 2024 - Wiley Online Library
Introduction. PPIs, or proton pump inhibitors, are the most widely prescribed drugs. There is
a debate regarding the relationship between long‐term PPI use and the risk of type 2 …
a debate regarding the relationship between long‐term PPI use and the risk of type 2 …