Using machine learning approaches for multi-omics data analysis: A review
With the development of modern high-throughput omic measurement platforms, it has
become essential for biomedical studies to undertake an integrative (combined) approach to …
become essential for biomedical studies to undertake an integrative (combined) approach to …
The Potential for Repurposing Anti-TNF as a Therapy for the Treatment of COVID-19
Summary Coronavirus disease 2019 (COVID-19) currently has few effective treatments.
Given the uncertainty surrounding the effectiveness and uptake of a vaccine, it is important …
Given the uncertainty surrounding the effectiveness and uptake of a vaccine, it is important …
ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for
coronavirus disease 2019 (COVID-19), continues to cause substantial morbidity and …
coronavirus disease 2019 (COVID-19), continues to cause substantial morbidity and …
Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19
Although critical for host defense, innate immune cells are also pathologic drivers of acute
respiratory distress syndrome (ARDS). Innate immune dynamics during Coronavirus …
respiratory distress syndrome (ARDS). Innate immune dynamics during Coronavirus …
Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly
infectious respiratory virus which is responsible for the coronavirus disease 2019 (COVID …
infectious respiratory virus which is responsible for the coronavirus disease 2019 (COVID …
The autoimmune signature of hyperinflammatory multisystem inflammatory syndrome in children
RA Porritt, A Binek, L Paschold… - The Journal of …, 2021 - Am Soc Clin Investig
Multisystem inflammatory syndrome in children (MIS-C) manifests as a severe and
uncontrolled inflammatory response with multiorgan involvement, occurring weeks after …
uncontrolled inflammatory response with multiorgan involvement, occurring weeks after …
Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19
Our understanding of protective versus pathological immune responses to SARS-CoV-2, the
virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling of …
virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling of …
A time-resolved proteomic and prognostic map of COVID-19
V Demichev, P Tober-Lau, O Lemke, T Nazarenko… - Cell systems, 2021 - cell.com
COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection
to severe organ damage and death. We characterized the time-dependent progression of …
to severe organ damage and death. We characterized the time-dependent progression of …
Functional landscape of SARS-CoV-2 cellular restriction
L Martin-Sancho, MK Lewinski, L Pache, CA Stoneham… - Molecular cell, 2021 - cell.com
A deficient interferon (IFN) response to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection has been implicated as a determinant of severe coronavirus …
(SARS-CoV-2) infection has been implicated as a determinant of severe coronavirus …
SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care
Prognostic characteristics inform risk stratification in intensive care unit (ICU) patients with
coronavirus disease 2019 (COVID-19). We obtained blood samples (n= 474) from …
coronavirus disease 2019 (COVID-19). We obtained blood samples (n= 474) from …