This review commemorates the 40th anniversary of DNA sequencing, a period in which we
have already witnessed multiple technological revolutions and a growth in scale from a few …

The term next-generation sequencing is almost a decade old, but it remains the colloquial
way to describe highly parallel or high-output sequencing methods that produce data at or …

In the burgeoning field of epigenetics, there are several methods available to determine the
methylation status of DNA samples. However, choosing the method that is best suited to …

Exome sequencing—the targeted sequencing of the subset of the human genome that is
protein coding—is a powerful and cost-effective new tool for dissecting the genetic basis of …

Background: Currently, a lack of consensus exists on how best to perform and interpret
quantitative real-time PCR (qPCR) experiments. The problem is exacerbated by a lack of …

Demand has never been greater for revolutionary technologies that deliver fast, inexpensive
and accurate genome information. This challenge has catalysed the development of next …

As most biologists are probably aware, technological advances in molecular biology during
the last few years have opened up possibilities to rapidly generate large-scale sequencing …

The sequence of the human genome has dramatically accelerated biomedical research.
Here I explore its impact, in the decade since its publication, on our understanding of the …

Allelic variations within a genome of the same species can be classified into three major
groups that include differences in the number of tandem repeats at a particular locus …

DNA sequence represents a single format onto which a broad range of biological
phenomena can be projected for high-throughput data collection. Over the past three years …