Phosphinic acids: current status and potential for drug discovery
Highlights•The rational design of phosphinic acids as medicinal agents towards a number of
diseases.•The current status of the phosphinate based prodrugs and drug delivery …
diseases.•The current status of the phosphinate based prodrugs and drug delivery …
Synopsis of recent synthetic methods and biological applications of phosphinic acid derivatives
MM Abdou - Tetrahedron, 2020 - Elsevier
The chemistry of phosphinic acid derivatives has attracted increasing attention in both
synthetic organic and biological fields, and great progress in the application of such …
synthetic organic and biological fields, and great progress in the application of such …
Molecular dynamics reveal binding mode of glutathionylspermidine by trypanothione synthetase
O Koch, D Cappel, M Nocker, T Jäger, L Flohé… - PLoS …, 2013 - journals.plos.org
The trypanothione synthetase (TryS) catalyses the two-step biosynthesis of trypanothione
from spermidine and glutathione and is an attractive new drug target for the development of …
from spermidine and glutathione and is an attractive new drug target for the development of …
Synthesis and biological applications of phosphinates and derivatives
D Virieux, JN Volle, N Bakalara, JL Pirat - Phosphorus Chemistry I …, 2015 - Springer
This review first outlines general considerations on phosphinic acids and derivatives as
bioisosteric groups. The next sections present key aspects of phosphinic acid-based …
bioisosteric groups. The next sections present key aspects of phosphinic acid-based …
[HTML][HTML] Characterisation of the bifunctional dihydrofolate synthase–folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial …
P Wang, Q Wang, Y Yang, JK Coward, A Nzila… - Molecular and …, 2010 - Elsevier
Unusually for a eukaryote, the malaria parasite Plasmodium falciparum expresses
dihydrofolate synthase (DHFS) and folylpolyglutamate synthase (FPGS) as a single …
dihydrofolate synthase (DHFS) and folylpolyglutamate synthase (FPGS) as a single …
[PDF][PDF] Synthesis of a new class of phosphinic derivatives as putative protease inhibitors
MM Abdou - 2019 - livrepository.liverpool.ac.uk
Introduction: aims to highlight the most important breakthroughs of phosphinic acids with a
broad range of pharmacological activities towards many diseases, such as anti-depressant …
broad range of pharmacological activities towards many diseases, such as anti-depressant …
Synthèse de nouveaux phosphinosucres et pseudo-disaccharides à activité anticancéreuse
R Babouri - 2016 - theses.hal.science
Les Phostines représentent une nouvelle classe de glycomimétiques contenant un atome
de phosphore à la place du carbone anomérique. Leur synthèse a été réalisée par la …
de phosphore à la place du carbone anomérique. Leur synthèse a été réalisée par la …
[PDF][PDF] Molecular Dynamics Reveal Binding Mode of Glutathionylspermidine by Trypanothione
O Koch, D Cappel, M Nocker, T Jäger, L Flohé - 2013 - researchgate.net
The trypanothione synthetase (TryS) catalyses the two-step biosynthesis of trypanothione
from spermidine and glutathione and is an attractive new drug target for the development of …
from spermidine and glutathione and is an attractive new drug target for the development of …