Cholesterol, inflammation and innate immunity

AR Tall, L Yvan-Charvet - Nature Reviews Immunology, 2015 - nature.com
Hypercholesterolaemia leads to cholesterol accumulation in macrophages and other
immune cells, which promotes inflammatory responses, including augmentation of Toll-like …

Causes and mechanisms of adipocyte enlargement and adipose expansion

F Haczeyni, KS Bell‐Anderson, GC Farrell - Obesity reviews, 2018 - Wiley Online Library
Adipose tissue plays a significant role in whole body energy homeostasis. Obesity‐
associated diabetes, fatty liver and metabolic syndrome are closely linked to adipose stress …

Interaction between adipocytes and high-density lipoprotein: new insights into the mechanism of obesity-induced dyslipidemia and atherosclerosis

T Zhang, J Chen, X Tang, Q Luo, D Xu, B Yu - Lipids in Health and …, 2019 - Springer
Obesity is the most common nutritional disorder worldwide and is associated with
dyslipidemia and atherosclerotic cardiovascular disease. The hallmark of dyslipidemia in …

Serum amyloid A impairs the antiinflammatory properties of HDL

CY Han, C Tang, ME Guevara, H Wei… - The Journal of …, 2016 - Am Soc Clin Investig
HDL from healthy humans and lean mice inhibits palmitate-induced adipocyte inflammation;
however, the effect of the inflammatory state on the functional properties of HDL on …

Lipid rafts as a therapeutic target: thematic review series: biology of lipid rafts

D Sviridov, N Mukhamedova, YI Miller - Journal of lipid research, 2020 - ASBMB
Lipid rafts regulate the initiation of cellular metabolic and signaling pathways by organizing
the pathway components in ordered microdomains on the cell surface. Cellular responses …

Is a high HDL-cholesterol level always beneficial?

B Franczyk, J Rysz, J Ławiński, M Rysz-Górzyńska… - Biomedicines, 2021 - mdpi.com
The specific interest concerning HDL cholesterol (HDL-C) is related to its ability to uptake
and return surplus cholesterol from peripheral tissues back to the liver and, therefore, to its …

Nanoparticles surface chemistry influence on protein corona composition and inflammatory responses

LE González-García, MN MacGregor, RM Visalakshan… - Nanomaterials, 2022 - mdpi.com
Nanoparticles are widely used for biomedical applications such as vaccine, drug delivery,
diagnostics, and therapeutics. This study aims to reveal the influence of nanoparticle surface …

Interactive effect of increased high sensitive C-reactive protein and dyslipidemia on cardiovascular diseases: a 12-year prospective cohort study

SEC Bafei, X Zhao, C Chen, J Sun, Q Zhuang… - Lipids in health and …, 2023 - Springer
Background Dyslipidemia and inflammation are significant factors for the onset of
cardiovascular diseases (CVD); however, studies regarding their interactions on the risk of …

HDL-mediated mechanisms of protection in cardiovascular disease

A Kontush - Cardiovascular research, 2014 - academic.oup.com
Low plasma levels of HDL-cholesterol (HDL-C) represent a strong and independent risk
factor for cardiovascular disease. HDL particles display a wide spectrum of atheroprotective …

The associations of lipid profiles with cardiovascular diseases and death in a 10-year prospective cohort study

J Dong, S Yang, Q Zhuang, J Sun, P Wei… - Frontiers in …, 2021 - frontiersin.org
Background: Dyslipidemia is one of the modifiable risk factors for cardiovascular diseases
(CVD). Identifying subjects with lipid abnormality facilitates preventative interventions …