The annual incidence of venous thrombosis, one of the leading causes of mortality and
morbidity, increases from 1 per 100,000 during childhood to 1 per 100 in old age. 1 In this …

Hemostasis is a physiologic mechanism that maintains blood in a fluid state within the
circulation. The coagulation of blood is mediated by cellular components and soluble …

According to a recent hypothesis, venous thrombosis results from the concurrence of several
factors. This hypothesis was assessed in patients with portal or hepatic venous thrombosis …

Rudolf Virchow, the brilliant 19th century pathologist, was the first to recognize that blood
clots in the pulmonary artery originate as venous thrombi. He stated:“The detachment of …

Factor V Leiden and factor II G20210A mutations are two frequent genetic risk factors
involved in venous thromboembolism (VTE). The goal of this pooled analysis of 8 case …

Background Point mutations in the factor V gene (factor V Leiden) and the prothrombin gene
(the substitution of A for G at position 20210) are the most common causes of inherited …

We conducted a systematic and comprehensive meta-analysis on all candidate genes to
assess their genetic contribution to the aetiology of venous thromboembolism …

The prevalence and pathogenesis of portal vein thrombosis (PVT) in patients with cirrhosis
without hepatocellular carcinoma are not clearly defined. The role of thrombophilic genetic …

Introduction: Fifty-three years after the first description of an inherited prothrombotic
condition (antithrombin deficiency), our knowledge on hereditary and acquired causes of …

Venous thromboembolism is a serious disorder because of its potential complications, such
as pulmonary embolism and the post-thrombotic syndrome. Inherited determinants of …