This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …

Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …

In the last century, small-molecule natural products were the main inspiration for most drug
discovery programs based either on high-throughput screening (HTS) or rational design …

Disulfide bridges establish a fundamental element in the molecular architecture of proteins
and peptides which are involved eg, in basic biological processes or acting as toxins. NMR …

Human transglutaminase 2 (TG2), a member of a large family of enzymes that catalyze
protein crosslinking, plays an important role in the extracellular matrix biology of many …

This review provides a comprehensive overview of the functional roles of disulfide bonds
and their relevance to human disease. The critical roles of disulfide bonds in protein …

It has been known for many decades that cell surface, soluble-secreted, and extracellular
matrix proteins are generally rich in disulfide bonds, but only more recently has the …

The molecular mechanisms underlying thiol-based redox control are poorly defined.
Disulfide bonds between Cys residues are commonly thought to confer extra rigidity and …

Significance: Among trace elements used as cofactors in enzymes, selenium is unique in
that it is incorporated into proteins co-translationally in the form of an amino acid …

Wnts are evolutionarily conserved ligands that signal at short range to regulate
morphogenesis, cell fate, and stem cell renewal. The first and essential steps in Wnt …