SARM1, an executor of axonal degeneration, displays NADase activity that depletes the key
cellular metabolite, NAD+, in response to nerve injury. The basis of SARM1 inhibition and its …

Image processing in cryogenic electron tomography (cryoET) is currently at a similar state as
Single Particle Analysis (SPA) in cryogenic electron microscopy (cryoEM) was a few years …

Wallerian axonal degeneration (WD) does not occur in the nematode C. elegans, in contrast
to other model animals. However, WD depends on the NADase activity of SARM1, a protein …

Using a new consensus-based image-processing approach together with principal
component analysis, the flexibility and conformational dynamics of the SARS-CoV-2 spike in …

Xmipp is an open-source software package consisting of multiple programs for processing
data originating from electron microscopy and electron tomography, designed and managed …

Virtual drug screening (VDS) tackles the problem of drug discovery by computationally
reducing the number of potential pharmacological molecules that need to be tested …

Enteric adenoviruses, one of the main causes of viral gastroenteritis in the world, must
withstand the harsh conditions found in the gut. This requirement suggests that capsid …

In recent years, there has been growing interest in SARM1 as a potential breakthrough drug
target for treating various pathologies of axon degeneration. SARM1-mediated axon …

Of five known adenovirus genera, high-resolution structures are available only for
mammalian-infecting mastadenoviruses. We present the first high-resolution structure of an …

Cryo-electron microscopy has established as a mature structural biology technique to
elucidate the three-dimensional structure of biological macromolecules. The Coulomb …