[HTML][HTML] Impact of hydromechanical stress on CHO cells' metabolism and productivity: Insights from shake flask cultivations with online monitoring of the respiration …

A Neuss, JST Borges, N von Vegesack, J Büchs… - New …, 2024 - Elsevier
The hydromechanical stress is a relevant parameter for mammalian cell cultivations,
especially regarding scale-up processes. It describes the mechanical forces exerted on cells …

Scale‐down of CHO cell cultivation from shake flasks based on oxygen mass transfer allows application of parallelized, non‐invasive, and time‐resolved monitoring of …

N Ihling, C Berg, R Paul, LP Munkler… - Biotechnology …, 2023 - Wiley Online Library
Cultivating Chinese hamster ovary (CHO) cells in microtiter plates (MTPs) with time‐
resolved monitoring of the oxygen transfer rate (OTR) is highly desirable to provide process …

High‐sensitivity real‐time monitoring of pH and respiration activity unveils metabolic dynamics in shake flask cultures

B Sarikaya, K Günster, LA Grebe… - Biotechnology …, 2024 - Wiley Online Library
Erlenmeyer shake flasks are widely used during the first steps of bioprocess development.
Despite their broad application in academia and industry, shake flasks usually lack …

Online monitoring of the respiration activity in 96‐deep‐well microtiter plate Chinese hamster ovary cultures streamlines kill curve experiments

A Neuss, N von Vegesack, R Liepelt… - Biotechnology …, 2024 - Wiley Online Library
Cell line generation of mammalian cells is a time‐consuming and labor‐intensive process,
especially because of challenges in clone selection after transfection. Antibiotics are …

Efficacy of ceftiofur N-acyl homoserine lactonase niosome in the treatment of multi-resistant Klebsiella pneumoniae in broilers

RA Hosny, ZA El-Badiea, DMA Elmasry… - Veterinary Research …, 2023 - Springer
In this study, the efficiency of the ceftiofur N-acyl homoserine lactonase niosome against
multi-resistant Klebsiella pneumoniae in broilers was evaluated. Fifty-six K. pneumonia e …

[引用][C] Optimization of mutagenicity detection and inulosucrase production by monitoring the oxygen transfer rate in small-scale culture systems

EC Forsten - Dissertation, Rheinisch-Westfälische …