Poptosis or Peptide-Induced Transmembrane Pore Formation: A Novel Way to Kill Cancer Cells without Affecting Normal Cells
MR Pincus, M Silberstein, N Zohar, E Sarafraz-Yazdi… - Biomedicines, 2024 - mdpi.com
Recent advances in cancer treatment like personalized chemotherapy and immunotherapy
are aimed at tumors that meet certain specifications. In this review, we describe a new …
are aimed at tumors that meet certain specifications. In this review, we describe a new …
Anti-Cancer Peptide PNC-27 Kills Cancer Cells by Unique Interactions with Plasma Membrane-Bound hdm-2 and with Mitochondrial Membranes Causing …
P Krzesaj, V Adler, RD Feinman… - Annals of Clinical & …, 2024 - Assoc Clin Scientists
Objective We have previously shown that the anti-cancer peptide PNC-27 kills cancer cells
by co-localizing with membrane-expressed HDM-2, resulting in transmembrane pore …
by co-localizing with membrane-expressed HDM-2, resulting in transmembrane pore …
Molecular targeting of H/MDM-2 Oncoprotein in Human Colon Cancer Cells and stem-like colonic epithelial-derived progenitor cells
A Thadi, WF Morano, M Khalili, BD Babcock… - Anticancer …, 2021 - ar.iiarjournals.org
Background/Aim: We have tested whether the anticancer peptide, PNC-27, that kills cancer
cells but not normal cells by binding to cancer cell membrane HDM-2 forming pores, kills …
cells but not normal cells by binding to cancer cell membrane HDM-2 forming pores, kills …