Agnostic sequencing for detection of viral pathogens
NPG Gauthier, SD Chorlton, M Krajden… - Clinical microbiology …, 2023 - Am Soc Microbiol
The advent of next-generation sequencing (NGS) technologies has expanded our ability to
detect and analyze microbial genomes and has yielded novel molecular approaches for …
detect and analyze microbial genomes and has yielded novel molecular approaches for …
COVID-19: understanding inter-individual variability and implications for precision medicine
NL Pereira, F Ahmad, M Byku, NW Cummins… - Mayo Clinic …, 2021 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) is characterized by heterogeneity in
susceptibility to the disease and severity of illness. Understanding inter-individual variation …
susceptibility to the disease and severity of illness. Understanding inter-individual variation …
Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape
KR McCarthy, LJ Rennick, S Nambulli… - Science, 2021 - science.org
Zoonotic pandemics, such as that caused by severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2), can follow the spillover of animal viruses into highly susceptible human …
2 (SARS-CoV-2), can follow the spillover of animal viruses into highly susceptible human …
[HTML][HTML] Structural and functional analysis of the D614G SARS-CoV-2 spike protein variant
L Yurkovetskiy, X Wang, KE Pascal, C Tomkins-Tinch… - Cell, 2020 - cell.com
Summary The SARS-CoV-2 spike (S) protein variant D614G supplanted the ancestral virus
worldwide, reaching near fixation in a matter of months. Here we show that D614G was …
worldwide, reaching near fixation in a matter of months. Here we show that D614G was …
Waning and boosting of antibody Fc-effector functions upon SARS-CoV-2 vaccination
X Tong, RP McNamara, MJ Avendaño… - Nature …, 2023 - nature.com
Since the emergence of SARS-CoV-2, vaccines targeting COVID-19 have been developed
with unprecedented speed and efficiency. CoronaVac, utilising an inactivated form of the …
with unprecedented speed and efficiency. CoronaVac, utilising an inactivated form of the …
Unlocking capacities of genomics for the COVID-19 response and future pandemics
During the COVID-19 pandemic, genomics and bioinformatics have emerged as essential
public health tools. The genomic data acquired using these methods have supported the …
public health tools. The genomic data acquired using these methods have supported the …
FnCas9-based CRISPR diagnostic for rapid and accurate detection of major SARS-CoV-2 variants on a paper strip
The COVID-19 pandemic originating in the Wuhan province of China in late 2019 has
impacted global health, causing increased mortality among elderly patients and individuals …
impacted global health, causing increased mortality among elderly patients and individuals …
SARS-CoV-2 Spike protein variant D614G increases infectivity and retains sensitivity to antibodies that target the receptor binding domain
Virus genome sequence variants that appear over the course of an outbreak can be
exploited to map the trajectory of the virus from one susceptible host to another. While such …
exploited to map the trajectory of the virus from one susceptible host to another. While such …
Viral genomes reveal patterns of the SARS-CoV-2 outbreak in Washington State
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
gravely affected societies around the world. Outbreaks in different parts of the globe have …
gravely affected societies around the world. Outbreaks in different parts of the globe have …
Detergent modulates the conformational equilibrium of SARS-CoV-2 Spike during cryo-EM structural determination
The Spike glycoprotein of SARS-CoV-2 mediates viral entry into the host cell via the
interaction between its receptor binding domain (RBD) and human angiotensin-converting …
interaction between its receptor binding domain (RBD) and human angiotensin-converting …