DNA mismatch repair and genetic instability
BD Harfe, S Jinks-Robertson - Annual review of genetics, 2000 - annualreviews.org
▪ Abstract Mismatch repair (MMR) systems play a central role in promoting genetic stability
by repairing DNA replication errors, inhibiting recombination between non-identical DNA …
by repairing DNA replication errors, inhibiting recombination between non-identical DNA …
DNA mismatch repair: molecular mechanisms and biological function
MJ Schofield, P Hsieh - Annual Reviews in Microbiology, 2003 - annualreviews.org
▪ Abstract DNA mismatch repair (MMR) guards the integrity of the genome in virtually all
cells. It contributes about 1000-fold to the overall fidelity of replication and targets mispaired …
cells. It contributes about 1000-fold to the overall fidelity of replication and targets mispaired …
Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA
G Obmolova, C Ban, P Hsieh, W Yang - nature, 2000 - nature.com
DNA mismatch repair is critical for increasing replication fidelity in organisms ranging from
bacteria to humans. MutS protein, a member of the ABC ATPase superfamily, recognizes …
bacteria to humans. MutS protein, a member of the ABC ATPase superfamily, recognizes …
MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice
B Kneitz, PE Cohen, E Avdievich, L Zhu… - Genes & …, 2000 - genesdev.cshlp.org
Msh4 (MutS homolog 4) is a member of the mammalian mismatch repair gene family whose
members are involved in postreplicative DNA mismatch repair as well as in the control of …
members are involved in postreplicative DNA mismatch repair as well as in the control of …
Exo1 Roles for Repair of DNA Double-Strand Breaks and Meiotic Crossing Over in Saccharomyces cerevisiae
H Tsubouchi, H Ogawa - Molecular biology of the cell, 2000 - Am Soc Cell Biol
The MRE11, RAD50, and XRS2 genes of Saccharomyces cerevisiae are involved in the
repair of DNA double-strand breaks (DSBs) produced by ionizing radiation and by …
repair of DNA double-strand breaks (DSBs) produced by ionizing radiation and by …
The budding yeast Msh4 protein functions in chromosome synapsis and the regulation of crossover distribution
JE Novak, PB Ross-Macdonald, GS Roeder - Genetics, 2001 - academic.oup.com
The budding yeast MSH4 gene encodes a MutS homolog produced specifically in meiotic
cells. Msh4 is not required for meiotic mismatch repair or gene conversion, but it is required …
cells. Msh4 is not required for meiotic mismatch repair or gene conversion, but it is required …
exo1-Dependent Mutator Mutations: Model System for Studying Functional Interactions in Mismatch Repair
NS Amin, MN Nguyen, S Oh… - Molecular and cellular …, 2001 - Taylor & Francis
EXO1 interacts with MSH2 and MLH1 and has been proposed to be a redundant
exonuclease that functions in mismatch repair (MMR). To better understand the role of EXO1 …
exonuclease that functions in mismatch repair (MMR). To better understand the role of EXO1 …
The role of the DNA mismatch repair system in the cytotoxicity of the topoisomerase inhibitors camptothecin and etoposide to human colorectal cancer cells
S Jacob, M Aguado, D Fallik, F Praz - Cancer research, 2001 - AACR
The DNA mismatch repair (MMR) system is involved in the correction of base/base
mismatches and insertion/deletion loops arising during replication. In addition, some of the …
mismatches and insertion/deletion loops arising during replication. In addition, some of the …
DNA mismatch repair defects: role in colorectal carcinogenesis
S Jacob, F Praz - Biochimie, 2002 - Elsevier
The inactivation of the DNA mismah repair (MMR) system, which is associated with the
predisposition to the hereditary non-polyposis colorectal cancer (HNPCC), has also been …
predisposition to the hereditary non-polyposis colorectal cancer (HNPCC), has also been …
The meiosis-specific zip4 protein regulates crossover distribution by promoting synaptonemal complex formation together with zip2
T Tsubouchi, H Zhao, GS Roeder - Developmental cell, 2006 - cell.com
We have characterized Zip4 (aka Spo22), a meiosis-specific protein essential for
chromosome synapsis in budding yeast. In the absence of Zip4, the synaptonemal complex …
chromosome synapsis in budding yeast. In the absence of Zip4, the synaptonemal complex …