Therapeutic potential of brassinosteroids in biomedical and clinical research

S Kaur Kohli, A Bhardwaj, V Bhardwaj, A Sharma… - Biomolecules, 2020 - mdpi.com
Steroids are a pivotal class of hormones with a key role in growth modulation and signal
transduction in multicellular organisms. Synthetic steroids are widely used to cure large …

Endothelial Cdk5 deficit leads to the development of spontaneous epilepsy through CXCL1/CXCR2-mediated reactive astrogliosis

X Liu, L Yang, L Shao, Y He, G Wu, Y Bao… - Journal of Experimental …, 2020 - rupress.org
Blood–brain barrier (BBB) dysfunction has been suggested to play an important role in
epilepsy. However, the mechanism mediating the transition from cerebrovascular damage to …

Cancer and brassinosteroids: Mechanisms of action, SAR and future perspectives

M Lorca, D Cabezas, I Araque, A Terán, S Hernández… - Steroids, 2023 - Elsevier
Brassinosteroids are plant hormones whose main function is to stimulate plant growth.
However, they have been studied for their biological applications in humans …

Bioactive Steroids from the Red Sea Soft Coral Sinularia polydactyla

MA Tammam, L Rárová, M Kvasnicová, G Gonzalez… - Marine drugs, 2020 - mdpi.com
Six new (1, 2, 6, 8, 13, and 20) and twenty previously isolated (3–5, 7, 9–12, 14–19, and 21–
26) steroids featuring thirteen different carbocycle motifs were isolated from the organic …

Cytokinin plant hormones have neuroprotective activity in in vitro models of Parkinson's disease

G Gonzalez, J Grúz, CW D'Acunto, P Kaňovský… - Molecules, 2021 - mdpi.com
Cytokinins are adenine-based phytohormones that regulate key processes in plants, such
as cell division and differentiation, root and shoot growth, apical dominance, branching, and …

Principal Component Analysis to Assess the Changes of Yield and Quality of Two Pinellia ternata Cultivars After Brassinolide Treatments

C Guo, Y Shen, M Li, Y Chen, X Xu, J Chu… - Journal of Plant Growth …, 2022 - Springer
Brassinolide (BR) plays an important role in physiological and biochemical processes of
plants. The natural resources of Pinellia ternata (P. ternata) were gradually exhausted, while …

Atropisomeric 1-phenylbenzimidazoles affecting microtubule organization: influence of axial chirality

J Pospíšilová, T Heger, O Kurka… - Organic & …, 2024 - pubs.rsc.org
Benzimidazoles are frequently used in medicinal chemistry. Their anticancer effect is among
the most prominent biological activities exhibited by this scaffold. Although numerous …

Isolation and Bioactivity Evaluation of Sesquiterpenes from an Alcyonarian of the Genus Lemnalia from the Saudi Arabian Red Sea

A Koutsaviti, M Kvasnicová, G Gonzalez… - Chemistry & …, 2024 - Wiley Online Library
Over the last decades, soft corals have been proven a rich source of biologically active
compounds, featuring a wide range of chemical structures. Herein, we investigated the …

Anticancer potential of brassinosteroids

OV Panibrat, VN Zhabinskii, VA Khripach - Brassinosteroids: Plant Growth …, 2019 - Springer
In recent years, it was shown that brassinosteroids (BS) exert their effects not only on plants
but also on animals and man. Eventually, some of these effects allowed considering BS as …

Synthesis and Biological Evaluation of α-Tocopherol Derivatives as Potential Anticancer Agents

A Baj, L Rárová, A Ratkiewicz, M Strnad, S Witkowski - Processes, 2023 - mdpi.com
α-Tocopheryl succinate (α-TS) and α-tocopheryloxyacetic acid (α-TEA) are potent inducers
of apoptosis in cancer cells and efficient suppressors of tumors in experimental model …